Implant device for drug delivery
First Claim
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1. A method of preparing a coated nanoporous membrane comprising a plurality of nanopores, wherein each nanopore has a first open end and an interior, the method comprising:
- forming a reaction mixture under vapor deposition conditions in a reaction chamber wherein the reaction mixture comprises a coating agent and the nanoporous membrane, wherein the vapor deposition conditions are Atomic Layer Deposition conditions comprising a temperature of from about room temperature to less than 100°
C.,such that a portion of the interior of each nanopore is coated with the coating agent to form a coating layer.
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Abstract
The present invention provides a method for controlling the internal diameter of nanopores to afford nanopore membranes with a zero-order rate of release of a therapeutic agent.
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Citations
22 Claims
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1. A method of preparing a coated nanoporous membrane comprising a plurality of nanopores, wherein each nanopore has a first open end and an interior, the method comprising:
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forming a reaction mixture under vapor deposition conditions in a reaction chamber wherein the reaction mixture comprises a coating agent and the nanoporous membrane, wherein the vapor deposition conditions are Atomic Layer Deposition conditions comprising a temperature of from about room temperature to less than 100°
C.,such that a portion of the interior of each nanopore is coated with the coating agent to form a coating layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A device comprising:
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a capsule suitable for implantation; a reservoir encapsulated by the capsule, wherein the reservoir is suitable for containing a therapeutic agent; and a nanopore membrane attached to the capsule such that the nanopore membrane is in contact with the reservoir, wherein the nanopore membrane comprises a plurality of nanopores in fluid contact with the reservoir, wherein the nanopores have an interior with a coating layer on at least a portion of the interior, such that the plurality of nanopores is a diffusion pathway out of the reservoir for the therapeutic agent. - View Dependent Claims (21)
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22. A titania composition comprising
a titanium substrate; -
an amorphous titania layer on the titanium substrate, wherein the titania layer comprises TiOxCy, wherein subscript x is from about 1.5 to about 4.0, and subscript y is from 0 to about 1.0; and at least one layer of TiOx chemically bound to the amorphous titania layer, wherein subscript x is from about 1.5 to about 4.0.
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Specification