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Aerosol pirfenidone and pyridone analog compounds and uses thereof

  • US 9,770,443 B2
  • Filed: 01/09/2015
  • Issued: 09/26/2017
  • Est. Priority Date: 01/10/2014
  • Status: Active Grant
First Claim
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1. An aqueous solution for nebulized inhalation administration consisting of:

  • water;

    pirfenidone at a concentration from about 0.1 mg/mL to about 20 mg/mL;

    sodium citrate;

    citric acid;

    sodium chloride; and

    sodium saccharin wherein the molar ratio of sodium saccharin to pirfenidone is between 1 to 53.9 and 1 to 215.9;

    wherein the osmolality of the aqueous solution is from about 200 mOsmol/kg to about 500 mOsmol/kg; and

    wherein the pH of the solution is about 5 to about 6.

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