Semifluorinated alkane compositions
First Claim
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1. A stable liquid composition comprising an active compound with more than one aliphatic double bond prone to oxidation, wherein the active compound is dissolved in a liquid vehicle comprising a semifluorinated alkane of formula
F(CF2)n(CH2)mHwherein n and m are integers independently selected from the range of 3 to 20, and wherein the liquid vehicle is substantially free of water;
- andwherein the active compound is an omega-3 or omega-6 fatty acid or derivative thereof, or a mixture of omega-3 or omega-6 fatty acids or derivatives thereof;
and wherein the composition comprises about 0.01-10 wt. % of the active compound.
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Abstract
The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
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Citations
20 Claims
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1. A stable liquid composition comprising an active compound with more than one aliphatic double bond prone to oxidation, wherein the active compound is dissolved in a liquid vehicle comprising a semifluorinated alkane of formula
F(CF2)n(CH2)mHwherein n and m are integers independently selected from the range of 3 to 20, and wherein the liquid vehicle is substantially free of water; - and
wherein the active compound is an omega-3 or omega-6 fatty acid or derivative thereof, or a mixture of omega-3 or omega-6 fatty acids or derivatives thereof; and wherein the composition comprises about 0.01-10 wt. % of the active compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of stabilising an active compound with more than one aliphatic double bond prone to oxidation comprising the step of dissolving the active compound in a liquid vehicle comprising a semifluorinated alkane of formula
F(CF2)n(CH2)mHwherein n and m are integers independently selected from the range of 3 to 20 and wherein the liquid vehicle is substantially free of water; -
wherein the active compound is an omega-3 or omega-6 fatty acid or derivative thereof, or a mixture of omega-3 or omega-6 fatty acids or derivatives thereof; and wherein the composition comprises about 0.01-10 wt. % of the active compound. - View Dependent Claims (20)
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Specification