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Methods and apparatuses for coating balloon catheters

  • US 9,770,576 B2
  • Filed: 11/04/2015
  • Issued: 09/26/2017
  • Est. Priority Date: 08/29/2008
  • Status: Active Grant
First Claim
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1. A method for preparing a substantially uniformly coated medical device, comprising:

  • (1) preparing a coating solution consisting of a solvent, a therapeutic agent, and an additive, wherein;

    the therapeutic agent is chosen from paclitaxel, rapamycin, daunorubicin, doxorubicin, lapachone, vitamin D2, vitamin D3, and combinations thereof;

    the solvent is chosen from water, methanol, ethanol, isopropanol, acetone, dimethylformamide, tetrahydrofuran, methylethyl ketone, dimethylsulfoxide, acetonitrile, ethyl acetate, chloroform, and mixtures thereof; and

    the additive is chosen from sorbitol, octanoyl-N-methylglucamide, gluconolactone, lactobionic acid, a poly(ethylene glycol) sorbitan fatty ester, or a combination thereof;

    (2) loading a metering dispenser with the coating solution;

    (3) rotating the medical device about the longitudinal axis of the medical device and/or moving the medical device in a linear direction along the longitudinal or transverse axis of the medical device;

    (4) dispensing the coating solution from the metering dispenser onto a surface of the medical device and flowing the coating solution on the surface of the medical device while the medical device is rotating and/or linearly moving; and

    (5) evaporating the solvent, forming a substantially uniform coating layer on the medical device.

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