Ultrasound ablation catheter with cooling infusion and centering basket

• US 9,770,606 B2
• Filed: 10/13/2014
• Issued: 09/26/2017
• Est. Priority Date: 10/15/2013
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Pikus, Michael J., Edmunds, Kevin D., Jenson, Mark L.
• Primary Examiner(s): Schmidt, Emily
• Assistant Examiner(s): PENG, LAUREN MICHELE
• Application Number:
  US14/513,074
• Publication Number:
  US 20150105715A1
• Time in Patent Office: 1,079 Days
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2018/00279 deployable
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00797 measured by multiple temperature sensors
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2218/002 Irrigation
• CPC Class Codes: A61N 2007/0043 intra-cavitary
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

Systems for nerve and tissue modulation are disclosed. An illustrative system may include an intravascular nerve modulation system including a catheter shaft, a first flexible mount, and a cylindrical ablation transducer. The ablation transducer may be affixed to the catheter shaft through the flexible mount to allow an infusion fluid to pass through a lumen of the transducer. Another illustrative system may include an intravascular nerve modulation system including an expandable basket for centering an ablation tra7nsducer within a lumen.

Claims

1. An intravascular nerve modulation system, comprising:

an elongate shaft having a proximal end, a distal end, and an infusion lumen extending therebetween;

an ablation transducer comprising an ultrasound transducer affixed to the elongate shaft adjacent the distal end thereof;

an expandable basket having a proximal end and a distal end, the proximal end affixed to the elongate shaft proximal of a proximal end of the ablation transducer and the distal end is affixed to the elongate shaft distal of a distal end of the ablation transducer;

an infusion sheath secured adjacent to the distal end of the elongate shaft in fluid communication with the infusion lumen, wherein the infusion sheath extends over the ablation transducer and is located within the expandable basket;

wherein the system is configured to transport infusion fluid through the infusion lumen and past the ablation transducer thereby providing convective cooling to the ablation transducer; and

wherein the expandable basket is configured to actuate between a first collapsed configuration and a second expanded configuration.

2. The nerve modulation system of claim 1, further comprising one or more temperature sensors coupled to the expandable basket.

3. The nerve modulation system of claim 1, wherein the expandable basket comprises two or more generally longitudinally extending struts.

4. The nerve modulation system of claim 1, further comprising a pull wire affixed to one of the distal end or the proximal end of the expandable basket.

5. The nerve modulation system of claim 4, wherein actuation of the pull wire moves the expandable basket between the first collapsed position and the second expanded position.

6. The nerve modulation system of claim 1, wherein the expandable basket is configured to self-expand.

7. The intravascular nerve modulation system at claim 1, wherein the elongate shaft comprises a first tubular member and a second tubular member and wherein said infusion lumen is located between the first tubular member and the second tubular member.

8. The intravascular nerve modulation system of claim 1, wherein the ablation transducer is a hollow ablation transducer that comprises a transducer lumen in fluid communication with the infusion lumen.

9. The intravascular nerve modulation system of claim 8, further comprising a flexible mount, wherein the ablation transducer is affixed to the elongate shaft through the flexible mount, and wherein the flexible mount comprises one or more lumens establishing fluid communication between the infusion lumen and the transducer lumen to allow the infusion fluid to be transported through the transducer lumen.

10. An intravascular nerve modulation system, comprising:

an elongate shaft having a proximal end region, a distal end region and an infusion lumen extending therebetween;

an ablation transducer comprising an ultrasound transducer coupled to the distal end region of the shaft;

an expandable basket coupled to the distal end region of the shaft, the expandable basket having a proximal end disposed proximal of the ablation transducer and a distal end disposed distal of the ablation transducer;

an infusion sheath secured adjacent to the distal end of the elongate shaft in fluid communication with the infusion lumen, wherein the infusion sheath extends over the ablation transducer and is located within the expandable basket;

wherein the system is configured to transport infusion fluid through the infusion lumen and past the ablation transducer thereby providing convective cooling to the ablation transducer;

wherein the expandable basket is capable of shifting between a first configuration and an expanded configuration;

and a sensor coupled to the expandable basket.

11. The intravascular nerve modulation system claim 10, wherein the sensor includes a temperature sensor.

12. The intravascular nerve modulation system of claim 11, wherein the sensor is designed to monitor the temperature of a vessel wall during an ablation procedure.

13. The intravascular nerve modulation system claim 10, wherein the sensor includes an impedance sensor.

14. The intravascular nerve modulation system of claim 10, wherein the sensor is designed to contact a vessel wall during an ablation procedure.

15. The intravascular nerve modulation system of claim 10, wherein the sensor is designed to monitor the progress of an ablation procedure.

16. The intravascular nerve modulation system of claim 10, wherein the expandable basket includes a plurality of struts and wherein the sensor is coupled to one of the struts.

17. The intravascular nerve modulation system of claim 10, wherein a plurality of sensors are coupled to the expandable basket.

18. An intravascular nerve modulation system, comprising:

an elongate shaft having a proximal end region, a distal end region and an infusion lumen extending therebetween;

an ultrasound transducer coupled to the distal end region of the shaft;

an expandable basket coupled to the distal end region of the shaft, the expandable basket having a proximal end disposed proximal of the ultrasound transducer and a distal end disposed distal of the ultrasound transducer;

an infusion sheath secured adjacent to the distal end of the elongate shaft in fluid communication with the infusion lumen, wherein the infusion sheath extends over the ablation transducer and is located within the expandable basket;

wherein the system is configured to transport infusion fluid through the infusion lumen and past the ablation transducer thereby providing convective cooling to the ablation transducer;

wherein the expandable basket is capable of shifting between a first configuration and an expanded configuration;

a sensor coupled to the expandable basket;

wherein the sensor is capable of contacting a vessel wall when the basket is in the expanded configuration; and

wherein the sensor is designed to monitor the progress of ablation by the ultrasound transducer during an ablation procedure.

19. The intravascular nerve modulation system claim 18, wherein the sensor includes a temperature sensor, an impedance sensor, or both.