Foam-formed collagen strand

• US 9,771,410 B2
• Filed: 07/17/2014
• Issued: 09/26/2017
• Est. Priority Date: 04/23/2010
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Lauritzen, Nels, Shimp, Lawrence A., Mitchell, Brent S.
• Primary Examiner(s): Milligan, Adam C
• Assistant Examiner(s): Alawadi, Sarah
• Application Number:
  US14/334,345
• Publication Number:
  US 20140329993A1
• Time in Patent Office: 1,167 Days
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/122 Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61L 17/08 of animal origin, e.g. catgut, collagen
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: C07K 14/78 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• CPC Class Codes: C08J 2201/0484 the liquid phase being aqueous
• CPC Class Codes: C08J 2389/00 Characterised by the use of proteins; Derivatives thereof
• CPC Class Codes: C08J 9/28 by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum

Abstract

Foam-formed collagen strands and methods for forming strands involve depositing a dispersed solution of an isolated cleaned, de-fatted, enzymatically-treated (or non-enzyme treated) human-derived collagen product having a preserved amount of its natural constituents into grooves of a grooved plate, and processing the dispersed collagen product to provide a foam-formed collagen strand. Foam-formed collagen strands may be processed into threads having a matrix of reticulated pores to conduct biological materials in and through the strand, the collagen of the collagen strand comprising isolated, enzymatically-treated human derived collagen having a preserved amount of its natural collagen constituents.

Claims

1. A method for preparing a foam-formed human collagen strand, having a matrix of reticulated pores with a pore size from greater than 1 mm to less than 2 mm configured to allow movement of cells and fluid in and along the length of the strand, the method comprising:

depositing a dispersed solution of an enzymatically-treated human-derived collagen product having a preserved amount of one or more native constituents into grooves of a grooved template to form a dispersed collagen product in said dispersed solution; and

processing the dispersed collagen product to provide said foam-formed human collagen strand;

wherein the matrix of reticulated pores comprises intersecting embossed surface channels to form a surface topography, and wherein the intersecting embossed surface channels include an axial channel extending between an embossed top surface channel intersection point and an embossed bottom surface channel intersection point.

2. The method of claim 1, wherein the dispersed collagen product has a collagen density from about 0.1% to about 10%.

3. The method of claim 1, wherein the dispersed collagen product comprises a sufficient amount of ethanol in the dispersion to prevent ice crystal formation and sharding.

4. The method of claim 1, wherein said processing comprises removing the liquid component of the dispersed solution.

5. The method of claim 1, wherein said processing comprises removing the liquid component by lyophilizing the dispersed solution.

6. The method of claim 1, wherein said processing comprises cross-linking the collagen in said collagen dispersion.

7. The method of claim 1, further comprising:

removing the foam-formed human collagen strand from the grooved plate; and

cross-linking the foam-formed collagen strand.

8. The method of claim 1, further comprising:

compressing the foam-formed collagen strand; and

twisting the foam-formed collagen strand.

9. The method of claim 1, further comprising coating the foam-formed human collagen strand with additional collagen, or a therapeutic agent that is released over time.

10. The method of claim 1, further comprising adjusting the foam density or the porosity of the foam-formed collagen strand to match a resorption rate of the strand to a healing rate of a repair site.

11. The method of claim 1, wherein said processing further comprises removing a liquid component by lyophilizing the dispersed solution, removing the foam-formed human collagen strand from the grooved plate, cross-linking the foam-formed collagen strand and adjusting the foam density or the porosity of the foam-formed collagen strand to match a resorption rate of the strand to a healing rate of a repair site.