Chemical approaches for generation of induced pluripotent stem cells
First Claim
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1. A composition comprising:
- (i) a mammalian non-pluripotent cell comprising exogenous polynucleotides comprising an Oct4 encoding polynucleotide and a Klf encoding polynucleotide; and
(ii) a small molecule composition comprising a GSK-3 inhibitor.
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Abstract
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
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12 Claims
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1. A composition comprising:
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(i) a mammalian non-pluripotent cell comprising exogenous polynucleotides comprising an Oct4 encoding polynucleotide and a Klf encoding polynucleotide; and (ii) a small molecule composition comprising a GSK-3 inhibitor. - View Dependent Claims (2, 3, 4, 5)
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6. The composition of 1, wherein the mammalian non-pluripotent cell is contacted with exogenous polynucleotides comprising an Oct4 encoding polynucleotide and a Klf4 encoding polynucleotide to initiate reprogramming.
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7. A composition comprising:
- an induced pluripotent stem cell reprogrammed from a mammalian non-pluripotent cell, and a small molecule composition comprising a GSK-3 inhibitor.
- View Dependent Claims (8, 9, 10, 11, 12)
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