Analyte sensors having a membrane with low temperature sensitivity
First Claim
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1. A system comprising:
- an analyte sensor comprising;
a counter electrode;
a working electrode comprising a sensing layer thereon, the sensing layer comprising an analyte responsive enzyme; and
a diffusion limiting polymeric membrane disposed on the sensing layer, wherein the polymeric membrane comprises a poly(4-vinylpyridine)-co-polystyrene polymer, an ethylene oxide substituent and a propylene oxide substituent,wherein diffusion of an analyte through the diffusion limiting membrane to the sensing layer does not change more than 5% per °
C. over a range of physiological temperatures; and
an electrochemical sensor control unit comprising;
a housing; and
a transmitter for transmitting sensor signals from the electrochemical sensor.
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Abstract
Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
35 Citations
12 Claims
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1. A system comprising:
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an analyte sensor comprising; a counter electrode; a working electrode comprising a sensing layer thereon, the sensing layer comprising an analyte responsive enzyme; and a diffusion limiting polymeric membrane disposed on the sensing layer, wherein the polymeric membrane comprises a poly(4-vinylpyridine)-co-polystyrene polymer, an ethylene oxide substituent and a propylene oxide substituent, wherein diffusion of an analyte through the diffusion limiting membrane to the sensing layer does not change more than 5% per °
C. over a range of physiological temperatures; andan electrochemical sensor control unit comprising; a housing; and a transmitter for transmitting sensor signals from the electrochemical sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification