Temperature insensitive in vivo analyte devices, methods and systems

• US 9,775,549 B2
• Filed: 06/11/2015
• Issued: 10/03/2017
• Est. Priority Date: 08/15/2014
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ouyang, Tianmei, Feldman, Benjamin J., Hoss, Udo, Bommakanti, Balasubrahmanya S., Sandhu, Gurinder
• Primary Examiner(s): Woodward, Ana
• Application Number:
  US14/737,082
• Publication Number:
  US 20160045147A1
• Time in Patent Office: 845 Days
• Field of Search: None
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence

Abstract

Disclosed herein are membrane structures for use in analyte sensors, where the membrane structures exhibit low temperature sensitivity.

Claims

1. A membrane structure comprising:

an enzyme layer; and

a membrane disposed proximate the enzyme layer, wherein the membrane comprises;

a polymer comprising a heterocyclic nitrogen containing component; and

a monoamine polyetheramine component that is covalently bonded to the nitrogen of the heterocyclic nitrogen containing component of the polymer.

2. The membrane structure according to claim 1, wherein the heterocyclic nitrogen containing component comprising a heteroaromatic ring system.

3. The membrane structure of claim 1, wherein the polymer comprises a heterocyclic nitrogen containing component is a poly(4-vinylpyridine-co-styrene) polymer.

4. The membrane structure of claim 3, wherein the poly(4-vinylpyridine-co-styrene) polymer comprises a compound of the formula:

5. The membrane structure of claim 4, wherein the ratio of x and y is from 1:

1 and 5;

1.

6. The membrane structure of claim 1, wherein the monoamine polyetheramine component comprises a polyethylene oxide component and polypropylene oxide component.

7. The membrane structure of claim 6, wherein the molar ratio of the polypropylene oxide component and polyethylene oxide component is 1:

35 to 35;

1.

8. The membrane structure of claim 1, wherein the monoamine polyetheramine component has a molecular weight of 500 daltons to 5000 daltons.

9. The membrane structure of claim 1, wherein the monoamine polyetheramine component comprises a compound of the formula:

10. The membrane structure of claim 1, wherein the membrane is disposed on the enzyme layer.