Systems and methods for applying scaling laws of tree structures

• US 9,775,576 B2
• Filed: 03/11/2014
• Issued: 10/03/2017
• Est. Priority Date: 01/23/2007
• Status: Active Grant

• Current Assignee: DTherapeutics LLC
• Original Assignee: DTherapeutics LLC
• Inventors: Kassab, Ghassan S., Huo, Yunlong
• Primary Examiner(s): Le, John H
• Application Number:
  US14/205,035
• Publication Number:
  US 20140257078A1
• Time in Patent Office: 1,302 Days
• Field of Search: 702 19, 702156, 702157, 702158, 600420, 600431, 600454, 600481, 600508, 600538, 703 11
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography

Abstract

Methods are provided for determining flow resistance within at least a portion of a vessel, whereby at least a partial biological tree image is obtained and resistance is calculated therefrom based upon at least the length of a defined vessel portion and a diameter of a stem vessel at a location proximal to a vessel crown. Methods are also provided for determining vessel volume, whereby at least a partial biological tree image is obtained and cumulative crown volume is calculated based on at least the diameter and length of the stem segment.

Claims

1. A method for diagnosing and treating disease in a patient'"'"'s biological tree, the method comprising the steps of:

using a processor to produce an image showing a vasculature of at least part of a patient'"'"'s biological tree, wherein the processor is operably connected to a storage medium capable of receiving and storing the image;

calculating patient resistance based upon at least a length of a patient vessel portion and a diameter of a patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image;

obtaining a model biological tree image and comparing the calculated patient resistance to a calculated model resistance calculated from the model biological tree image to determine the extent of vessel and/or organ disease; and

treating the patient based on the determined extent of vessel and/or organ disease.

2. The method of claim 1, wherein the calculated model resistance is based upon at least a length of a model vessel portion and a diameter of a model stem vessel proximal to the vessel crown from the model biological tree image.

3. The method of claim 1, wherein the patient resistance is a resistance of a stem segment, and wherein the length of the patient vessel portion is a length of a stem.

4. The method of claim 1, wherein the patient resistance is a resistance of a crown, and wherein the length of the patient vessel portion is a crown length.

5. The method of claim 1, wherein the patient resistance is a total resistance of the biological tree, and wherein the length of the patient vessel portion is a cumulative biological tree vessel length.

6. The method of claim 1, wherein the patient resistance is the resistance of blood within a vessel portion.

7. The method of claim 1, wherein the patient vessel portion comprises a vessel selected from the group consisting of a blood vessel, a bile duct, a lung, and a neuron.

8. The method of claim 1, wherein the patient resistance is the resistance of a gas within a vessel portion.

9. The method of claim 8, wherein the gas comprises breathable air, and wherein the vessel portion comprises a portion of a lung.

10. The method of claim 1, wherein the extent of vessel and/or organ disease is indicative of a disease selected from the group consisting of diffuse coronary artery disease, hypertension, atherosclerosis, heart failure, myocardial ischemia, myocardial infarction, an edematous disorder, and postural tachycardia syndrome.

11. A method for diagnosing and treating disease in a patient'"'"'s biological tree, the method comprising the steps of:

using a processor to produce an image showing a vasculature of at least part of a patient'"'"'s biological tree, wherein the processor is operably connected to a storage medium capable of receiving and storing the image;

calculating patient cumulative crown volume based upon at least a diameter of a patient stem segment and a length of a patient stem segment from the patient'"'"'s biological tree image;

obtaining a model biological tree image and comparing the calculated patient cumulative crown volume to a calculated model cumulative crown volume calculated from the model biological tree image to determine the extent of vessel and/or organ disease; and

treating the patient if the determined extent of the vessel and/or organ disease indicates an inefficiency of the vasculature.

12. The method of claim 11, wherein the calculated model cumulative crown volume is based upon at least a diameter of a model stem segment and a length of a model stem segment from the model biological tree image.

13. The method of claim 11, wherein the step of comparing the calculated patient cumulative crown volume to the calculated model cumulative crown volume is performed by graphically comparing calculated model cumulative crown volume data to calculated model cumulative crown volume data to determine the extent of vessel and/or organ disease by identifying one or more graphical differences between said data.

14. The method of claim 11, wherein the step of comparing the calculated patient cumulative crown volume to the calculated model cumulative crown volume is performed by comparing calculated model cumulative crown volume data to calculated model cumulative crown volume data in table form to determine the extent of vessel and/or organ disease by identifying one or more numerically calculated differences between said data.

15. The method of claim 11, wherein the method further comprises the steps of:

identifying a most proximal patient stem diameter from the patient'"'"'s biological tree image;

identifying a patient'"'"'s cumulative biological tree vessel length from the patient'"'"'s biological tree image; and

calculating a patient'"'"'s cumulative biological tree volume of the patient'"'"'s biological tree based upon at least the most proximal patient stem diameter and the patient'"'"'s cumulative biological tree vessel length.

16. The method of claim 15, further comprising the step of determining a structure-function scaling relation, wherein the structure-function scaling relation comprises a first component and a second component, or a mathematical equivalent thereof.

17. The method of claim 16, further comprising the step of determining a non-dimensional structure-function scaling relation, wherein the non-dimensional structure-function scaling relation comprises a first component, a second component, and a third component, or a mathematical equivalent thereof.

18. The method of claim 11, wherein the calculated patient'"'"'s cumulative crown volume provides information useful for a diagnosis of a disease.

19. The method of claim 11, wherein the extent of vessel and/or organ disease is indicative of a disease selected from the group consisting of diffuse coronary artery disease, hypertension, atherosclerosis, heart failure, myocardial ischemia, myocardial infarction, an edematous disorder, and postural tachycardia syndrome.

20. A system for diagnosing disease in a patient'"'"'s biological tree, the system comprising:

a processor;

a storage medium operably connected to the processor, the storage medium capable of receiving and storing data relative of measurements from a vasculature of a vessel;

wherein the processor is operable to;

produce an image showing a vasculature of at least part of a patient'"'"'s biological tree, the image to be received and stored in the storage medium;

calculate patient resistance based upon at least a length of a patient vessel portion and a diameter of a patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image; and

obtain a model biological tree image and compare the calculated patient resistance to a calculated model resistance calculated from the model biological tree image to determine the extent of vessel and/or organ disease.