Hydrogel polymeric compositions and methods
First Claim
Patent Images
1. A synthetic, biocompatible polymeric hydrogel for delivering a therapeutic agent to an eye comprising:
- a first water soluble synthetic precursor covalently crosslinked to form the biocompatible hydrogel,a hydrophobic drug in a particulate form free of encapsulating materials and being in direct contact with the hydrogel that is released from the hydrogel during a period of time within a range from two months to two years,wherein, before crosslinking, the first precursor comprises a water-degradable group and the first precursor and any other precursors that contribute to form the hydrogel are free of hydrophobic polymeric blocks,wherein the hydrogel is internally covalently crosslinked and is low-swelling, as measurable by the hydrogel having a weight increasing no more than about 50% upon exposure to a physiological solution for twenty-four hours relative to a weight of the hydrogel at the time of formation, and wherein the hydrogel is water-degradable, as measurable by the hydrogel being dissolvable in vitro in an excess of water by degradation of the water-degradable group.
4 Assignments
0 Petitions
Accused Products
Abstract
Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
-
Citations
34 Claims
-
1. A synthetic, biocompatible polymeric hydrogel for delivering a therapeutic agent to an eye comprising:
a first water soluble synthetic precursor covalently crosslinked to form the biocompatible hydrogel, a hydrophobic drug in a particulate form free of encapsulating materials and being in direct contact with the hydrogel that is released from the hydrogel during a period of time within a range from two months to two years, wherein, before crosslinking, the first precursor comprises a water-degradable group and the first precursor and any other precursors that contribute to form the hydrogel are free of hydrophobic polymeric blocks, wherein the hydrogel is internally covalently crosslinked and is low-swelling, as measurable by the hydrogel having a weight increasing no more than about 50% upon exposure to a physiological solution for twenty-four hours relative to a weight of the hydrogel at the time of formation, and wherein the hydrogel is water-degradable, as measurable by the hydrogel being dissolvable in vitro in an excess of water by degradation of the water-degradable group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
18. A synthetic, biocompatible polymeric device for delivering a drug to an eye, the device consisting essentially of a hydrogel and a drug dispersed in the hydrogel, wherein the hydrogel is formed from one or more water soluble synthetic precursors covalently crosslinked to form the hydrogel, the drug is hydrophobic and in a particulate form free of encapsulating materials and in direct contact with the hydrogel, with the drug being released from the hydrogel during a period of time within a range from two months to two years,
wherein the hydrogel is free of hydrophobic polymeric blocks, wherein the hydrogel is internally covalently crosslinked and is low-swelling, as measurable by the hydrogel having a weight increasing no more than about 50% upon exposure to a physiological solution for twenty-four hours relative to a weight of the hydrogel at the time of formation, and wherein the hydrogel is water-degradable, as measurable by the hydrogel being dissolvable in vitro in an excess of water by degradation of the water-degradable group.
Specification