Pen-type injector

• US 9,775,954 B2
• Filed: 06/13/2016
• Issued: 10/03/2017
• Est. Priority Date: 03/03/2003
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Veasey, Robert Frederick, Perkins, Robert, Plumptre, David Aubrey
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US15/180,141
• Publication Number:
  US 20160303329A1
• Time in Patent Office: 477 Days
• Field of Search: 604208-211, 604 68, 128DIG 12, 128DIG 13
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31528 by means of rotational movements, e.g. screw-thread mechanisms
• CPC Class Codes: A61M 5/31533 Dosing mechanisms, i.e. setting a dose administrating mechanisms A61M5/31565
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31536 Blocking means to immobilize a selected dose, e.g. to administer equal doses
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31563 interacting with a displaceable stop member
• CPC Class Codes: A61M 5/31565 Administration mechanisms, i.e. constructional features, modes of administering a dose dosing mechanisms for setting a dose A61M5/31533
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31575 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 : Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/32 : Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001

Abstract

The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

Claims

1. A drug delivery device comprising:

a housing comprising (i) a thread, (ii) a dose dispensing end, and (iii) a stop member that is integral to the housing;

a dose dial sleeve disposed radially inward from the housing, the dose dial sleeve comprising a thread that engages with the thread of the housing;

a clutch disposed radially inward from the dose dial sleeve,

a piston rod;

wherein

the stop member is configured to engage the dose dial sleeve and prevent axial movement of a button away from the dose dispensing end;

the clutch is configured to be rotationally fixed to the dose dial sleeve during dose setting;

the piston rod is configured to traverse axially during dose dispensing; and

the button is configured to be depressed axially towards the dose dispensing end of the housing.

2. The drug delivery device of claim 1, wherein the clutch comprises a first set of splines.

3. The drug delivery device of claim 2, comprising a member with a second set of splines that engage with the first set of splines.

4. The drug delivery device of claim 3, wherein the button is configured to be depressed axially towards the dose dispensing end and is configured to disengage the first and the second sets of splines.

5. The drug delivery device of claim 1 wherein the piston rod comprises a rotating piston rod.

6. The drug delivery device of claim 5 wherein the rotating piston rod rotates during dose dispensing.

7. The drug delivery device of claim 1 wherein the housing comprises a main housing.

8. The drug delivery device of claim 1 wherein the clutch comprises a tubular clutch.

9. The drug delivery device of claim 8 wherein the tubular clutch is located adjacent a distal end of the button.

10. The drug delivery device of claim 9 wherein the tubular clutch is operatively coupled to the button.

11. The drug delivery device of claim 1 wherein the clutch comprises a series of teeth.

12. The drug delivery device of claim 11 wherein the clutch comprises a series of circumferentially directed saw teeth.

13. The drug delivery device of claim 1 wherein the clutch comprises a flange.

14. The drug delivery device of claim 1 further comprising

a clicker.

15. The drug delivery device of claim 14 wherein the clicker comprises

a cylindrical clicker.

16. The drug delivery device of claim 15 wherein the cylindrical clicker comprises

a flexible helically extending arm, and

a series of directed saw teeth.

17. The drug delivery device of claim 16 wherein the series of directed saw teeth comprise circumferentially directed saw teeth.

18. The drug delivery device of claim 17 wherein the cylindrical clicker further comprises a spring.

19. The drug delivery device of claim 1 wherein the piston rod further comprises a pressure foot located at a first end of the piston rod,

the pressure foot disposed to abut an end of a cartridge piston.

20. The drug delivery device of claim 1, further comprising

a removable cap that is configured to be releasably retained over a portion of the housing,

wherein an outer dimension of the removable cap is similar to an outer dimension of the housing.

21. The drug delivery device of claim 1 wherein the drug delivery device comprises a pen-type injector.

22. The drug delivery device of claim 1 wherein the housing is provided with a window through which part of an outer surface of the dose dial sleeve may be seen.

23. A drug delivery device comprising:

a housing comprising (i) a thread, (ii) a dose dispensing end, and (iii) a stop member that is integral to the housing;

a dose indicator disposed radially inward from the housing, the dose indicator comprising a thread that engages with the thread of the housing;

a clutch disposed radially inward from the dose indicator, the clutch comprising a first set of splines;

a sleeve disposed radially inward from the clutch, the sleeve comprising a second set of splines that engages with the first set of splines;

a rod engaged with the sleeve, the rod comprising a thread;

a button that is rotationally fixed to the sleeve;

wherein;

the stop member is configured to engage the dose indicator and prevent axial movement of the button away from the dose dispensing end;

the clutch is configured to be rotationally fixed to the dose indicator during dose setting;

the sleeve is configured to be rotationally fixed to the clutch during dose setting;

the dose indicator, clutch, and sleeve rotate during dose setting;

the rod is configured to traverse axially during dose dispensing;

the button is configured to be depressed axially towards the dose dispensing end and is configured to disengage the first and the second sets of splines.

24. The drug delivery device of claim 23 wherein the piston rod comprises a rotating piston rod.

25. The drug delivery device of claim 24 wherein the rotating piston rod rotates during dose dispensing.

26. The drug delivery device of claim 23 further comprising a clicker.

27. The drug delivery device of claim 26 wherein the clicker comprises

a cylindrical clicker.

28. The drug delivery device of claim 27 wherein the cylindrical clicker comprises

a flexible helically extending arm, and

a series of directed saw teeth.