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Reversing cognitive-motor impairments in patients having a neuro-degenerative disease using a computational modeling approach to deep brain stimulation programming

  • US 9,776,003 B2
  • Filed: 05/06/2016
  • Issued: 10/03/2017
  • Est. Priority Date: 12/02/2009
  • Status: Active Grant
First Claim
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1. A method for treating a neurological disorder that results in abnormal motor function, the method comprising:

  • determining, by a computer processor, an estimated volume of tissue activated (VTA) using a set of stimulation parameters, wherein the estimated VTA comprises at least a portion of at least one of the zona incerta, lenticular fasciculus, or motor region of the globus pallidus and the estimated VTA comprises less than 10% of non-motor anatomical-neural regions of a subthalamic nucleus;

    providing the set of stimulation parameters to a deep brain stimulation device comprising a leadwire and a plurality of electrodes disposed along the leadwire; and

    stimulating the portion of the at least one of the zona incerta, lenticular fasciculus, or motor region of the globus pallidus using the deep brain stimulation device and the set of stimulation parameters.

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