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Transvascular diaphragm pacing systems and methods of use

  • US 9,776,005 B2
  • Filed: 08/28/2015
  • Issued: 10/03/2017
  • Est. Priority Date: 06/21/2013
  • Status: Active Grant
First Claim
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1. A method of stimulating a diaphragm to provide a diaphragm assist level, comprising:

  • (a) obtaining an attribute of a breath cycle of a patient, wherein the patient receives respiratory assistance from a ventilator during the breath cycle;

    (b) based on a stimulation parameter, the attribute of the breath cycle, and a desired value of a breath parameter, transmitting a first stimulation signal to a first electrode positioned within a blood vessel of the patient such that the electrode recruits a phrenic nerve of the patient;

    (c) after transmitting the first stimulation signal, determining an actual value of the breath parameter from a breath;

    (d) comparing the actual value of the breath parameter to the desired value of the breath parameter; and

    (e) either (1) maintaining the stimulation parameter if the actual value of the breath parameter is within a selected range of the desired value of the breath parameter;

    or (2) modifying the stimulation parameter if the actual value of the breath parameter is not within the selected range of the desired value of the breath parameter; and

    (f) repeating steps (b)-(e),wherein the method further includes transmitting a second stimulation signal to a second electrode to recruit the phrenic nerve, and wherein transmitting the first stimulation signal to the first electrode occurs at a different time as transmitting the second stimulation signal to the second electrode.

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