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Methods for identifying modulators of ion channels

  • US 9,778,267 B2
  • Filed: 07/11/2008
  • Issued: 10/03/2017
  • Est. Priority Date: 07/11/2007
  • Status: Active Grant
First Claim
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1. A method of identifying a compound that is a modulator of an ion channel comprising:

  • (a) applying cells to a first location and a second location on a surface of colorimetric resonant reflectance optical biosensor;

    (b) applying a test reagent compound to the first location;

    (c) applying a compound that is a known ion channel modulator of the cells to the second location;

    (d) detecting a colorimetric resonant reflectance optical first peak wavelength value (PWV) for the first location and detecting a second PWV for the second location;

    wherein if the first and second PWVs are the same or similar, then the test reagent compound is a modulator of an ion channel; and

    wherein if the first and second PWVs are substantially different, then the test reagent is not a compound that is a modulator of an ion channel.

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