Magnetic resonance (MR) imaging generating perfusion images with arterial spin labeling (ASL) and 3D radial pulse sequences

• US 9,778,333 B2
• Filed: 05/23/2013
• Issued: 10/03/2017
• Est. Priority Date: 05/23/2013
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Sun, Wei, Wu, Gaohong G., Polzin, Jason Andrew, Shankaranarayanan, Ajit
• Primary Examiner(s): KOVAL, MELISSA J
• Assistant Examiner(s): Fetzner, Tiffany
• Application Number:
  US13/900,678
• Publication Number:
  US 20140347048A1
• Time in Patent Office: 1,594 Days
• Field of Search: 324300-322, 600407-435, 382128-131
• CPC Class Codes: G01R 33/3854 means for active and/or passive vibration damping or acoustical noise suppression in gradient magnet coil systems
• CPC Class Codes: G01R 33/4826 in three dimensions
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
• CPC Class Codes: G01R 33/56366 Perfusion imaging

Abstract

Systems and methods for reducing acoustic noise in a Magnetic Resonance Imaging (MRI) are provided. One method includes applying a labeling phase of an arterial spin labeling (ASL) pulse sequence to a region of interest, applying a three-dimensional (3D) radial pulse sequence to the region of interest to generate a tag image, applying a control phase of the ASL pulse sequence to the region of interest, and applying the 3D radial pulse sequence to the region of interest to generate a control image.

Claims

1. A method of generating a plurality of perfusion images, of a region of interest that are generated from k-space datasets in a magnetic resonance imaging (MRI) system, said method comprising:

activating a radio frequency (RF) coil of the MRI system in order to apply a labeling phase of an arterial spin labeling (ASL) pulse sequence to a region of interest;

generating a tag image of the region of interest with one or more processors of the MRI system, by applying a three-dimensional (3D) radial pulse sequence from the activated RF coil of the MRI system onto the region of interest;

activating the RF coil of the MRI system in order to apply a control phase of the ASL pulse sequence onto the region of interest, wherein the applied control phase modifies a frequency, a phase, or an amplitude of the ASL pulse sequence;

generating a control image of the region of interest with the one or more processor of the MRI system, by applying the 3D radial pulse sequence from the activated RF coil onto the region of interest;

using the one or more processors of the MRI system in order to subtract the generated control image from the generated tag image and in order to generate k-space datasets; and

using the one or more processors of the MRI system and the generated k-space data sets in order to generate a plurality of perfusion images of the region of interest.

2. The method of claim 1, wherein the 3D radial pulse sequence that is applied is configured to encode free-inductance decay responses along different angular orientations in k-spaces, such that the 3D radial pulse sequence acquires k-space data spiraling radially outward at a top portion of the region of interest and then spiraling radially inward until the radially inner bottom portion of the region of interest is acquired.

3. The method of claim 1, wherein the 3D radial pulse sequence includes a plurality of segments, and wherein the tag image and the control image are generated from the plurality of segments of the 3D radial pulse sequence.

4. The method of claim 3, wherein the subtracting operation includes subtracting the control image from the tag image, for each segment within the plurality of segments, in order to generate the k-space datasets for each segment.

5. The method of claim 1, further comprising:

applying an interpolation onto the generated k-space datasets with the one or more processors in order to generate a 3D Cartesian k-space dataset; and

Fourier transforming the generated 3D Cartesian k-space dataset, with the one or more processors in order to generate the plurality of perfusion images.

6. The method of claim 1, wherein the region of interest is an arterial blood flow region, and the plurality of perfusion images include a plurality of inflow perfusion images or inflow angiography images.

7. The method of claim 1, wherein the ASL pulse sequence generated by the RF coil includes a continuous ASL (CASL), a pulsed ASL (pASL), a pseudo continuous ASL with deteriorating (pCASL), or an amplitude modulated ASL (amCASL).

8. A non-transitory computer readable storage medium that is usable with a magnetic resonance imaging (MRI) system having one or more processors that generates k-space datasets and a plurality of perfusion images of a region of interest using the generated k-space datasets the non-transitory computer readable storage medium including instructions to command the one or more processors to:

activate a radio frequency (RF) coil in order to apply a labeling phase of an arterial spin labeling (ASL) pulse sequence to a region of interest;

generate a tag image of the region of interest with one or more processors of the MRI system, by applying a three-dimensional (3D) radial pulse sequence from the activated RF coil of the MRI system onto the region of interest;

activate the RF coil of the MRI system in order to apply a control phase of the ASL pulse sequence onto the region of interest, wherein the applied control phase modifies a frequency, a phase, or an amplitude of the ASL pulse sequence;

generate a control image of the region of interest with the one or more processors of the MRI system, by applying the 3D radial pulse sequence to the region of interest;

with the activated RF coil;

subtract the generated control image from the generated tag image in order to generate k-space datasets by using the one or more computer processors of the MRI system; and

generate a plurality of perfusion images of the region of interest from the generated k-space datasets with the one or more computer processors of the MRI system.

9. The non-transitory computer readable storage medium of claim 8, wherein the 3D radial pulse sequence that is applied is configured to encode free-inductance decay responses along different angular orientations in k-spaces, such that the 3D radial pulse sequence acquires k-space data spiraling radially outward at a top portion of the region of interest and then spiraling radially inward until the radially inner bottom portion of the region of interest is acquired.

10. The non-transitory computer readable storage medium of claim 8, wherein the 3D radial pulse sequence includes a plurality of segments, and wherein the tag image and the control image are generated from the plurality of segments of the 3D radial pulse sequence.

11. The non-transitory computer readable storage medium of claim 10, wherein the instructions command the processor to subtract the control image from the tag image, for each segment within the plurality of segments, in order to generate the k-space datasets for each segment.

12. The non-transitory computer readable storage medium of claim 8, wherein the instructions command the processor to:

apply an interpolation on the k-space datasets with the one or more processors in order to generate a 3D Cartesian k-space dataset; and

Fourier transforming the generated 3D Cartesian k-space dataset, with the one or more processors in order to generate the plurality of perfusion images;

wherein at least one of the one or more processors is further configured to apply an interpolation onto the generated k-space datasets, in order to generate a 3D Cartesian k-space dataset, and the at least one processor of the one or more processors is also configured to apply with the one or more processors a Fourier transform to each generated 3D Cartesian k-space dataset, that is generated order to generate the plurality of perfusion images.

13. The non-transitory computer readable storage medium of claim 8, wherein the instructions further command the one or more processors to acquire a tag image and a control image that are of an arterial blood flow interest is an arterial blood flow region, and the plurality of perfusion images include a plurality of inflow perfusion images or inflow angiography images, wherein the instructions command the processor to acquire that the tag image and the control image are of an arterial blood flow.

14. The non-transitory computer readable storage medium of claim 8, wherein the ASL pulse sequence generated by the RF coil includes a continuous ASL (CASL), a pulsed ASL (pASL), a pseudo continuous ASL with deteriorating (pCASL), or an amplitude modulated ASL (amCASL).

15. A Magnetic Resonance Imaging (MRI) system that generates a plurality of perfusion images, of a region of interest from k-space datasets that are generated from the application of an arterial spin labeling (ASL) pulse sequence and the application of a three-dimensional (3D) radial pulse sequence comprising:

a magnet having a plurality magnetic gradient coils, wherein the magnet is a superconducting magnet, a permanent magnet, or an electromagnet;

a radio frequency (RF) coil configured to provide transmission/reception of excitation pulse sequences;

a display; and

one or more processors configured to;

activate the RF coil in order to apply a labeling phase of an arterial spin labeling (ASL) pulse sequence to a region of interest;

generate a tag image of the region of interest by applying a three-dimensional (3D) radial pulse sequence with the activated RF coil onto the region of interest;

activate the RF coil in order to apply a control phase of the ASL pulse sequence onto the region of interest, wherein the applied control phase modifies a frequency, a phase, or an amplitude of the ASL pulse sequence; and

generate a control image of the region of interest by applying the 3D radial pulse sequence onto the region of interest with from the activated RF coil; and

subtract the generated control image from the generated tag image and thereby generate k-space datasets which are then utilized in generating a plurality of perfusion images based on the generated k-space datasets that are shown on the display.

16. The MRI system of claim 15, wherein the 3D radial pulse sequence that is applied is configured to encode free-inductance decay responses along different angular orientations in k-spaces, such that the 3D radial pulse sequence acquires k-space data spiraling radially outward at a top portion of the region of interest and then spiraling radially inward until the radially inner bottom portion of the region of interest is acquired.

17. The MRI system of claim 15, wherein the 3D radial pulse sequence includes a plurality of segments, and wherein the tag image and the control image are generated from the plurality of segments of the 3D radial pulse sequence.

18. The MRI system of claim, 17, wherein the subtracting operation includes subtracting the control image from the tag image, for each segment within the plurality of segments, in order to generate the k-space datasets for each segment.

19. The MRI system of claim 15, wherein at least one of the one or more processors is further configured to apply an interpolation onto the generated k-space datasets, in order to generate a 3D Cartesian k-space dataset, and the at least one processor of the one or more processors is also configured to apply with the one or more processors a Fourier transform to each generated 3D Cartesian k-space dataset, that is generated order to generate the plurality of perfusion images.

20. The MRI system of claim 15, wherein the ASL pulse sequence generated by the RF coil includes a continuous ASL (CASL), a pulsed ASL (pASL), a pseudo continuous ASL with deteriorating (pCASL), or an amplitude modulated ASL (amCASL).