Picosecond laser apparatus and methods for treating target tissues with same

• US 9,780,518 B2
• Filed: 03/15/2013
• Issued: 10/03/2017
• Est. Priority Date: 04/18/2012
• Status: Active Grant

• Current Assignee: Cynosure, LLC (Hologic Incorporated)
• Original Assignee: Cynosure Incorporated
• Inventors: Sierra, Rafael A., Mirkov, Mirko Georgiev
• Primary Examiner(s): Park, Kinam
• Application Number:
  US14/394,960
• Publication Number:
  US 20150180193A1
• Time in Patent Office: 1,663 Days
• Field of Search: 372 18, 372 12, 372 22, 372 21, 372 41, 372106, 372 98
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: F04C 2270/0421 Controlled or regulated
• CPC Class Codes: H01S 3/0627 the resonator being monolithic, e.g. microlaser
• CPC Class Codes: H01S 3/08054 Passive cavity elements acting on the polarization, e.g. a polarizer for branching or walk-off compensation quarter-wave plates in a Q-switch laser H01S3/1124, H01S3/115
• CPC Class Codes: H01S 3/094038 End pumping
• CPC Class Codes: H01S 3/094076 Pulsed or modulated pumping H01S3/1024 takes precedence
• CPC Class Codes: H01S 3/1024 for pulse generation
• CPC Class Codes: H01S 3/107 using electro-optic devices, e.g. exhibiting Pockels or Kerr effect H01S3/1061, H01S3/1063, H01S3/1065 take precedence
• CPC Class Codes: H01S 3/1075 for optical deflection
• CPC Class Codes: H01S 3/1103 Cavity dumping
• CPC Class Codes: H01S 3/1106 Mode locking
• CPC Class Codes: H01S 3/1109 Active mode locking
• CPC Class Codes: H01S 3/1611 neodymium
• CPC Class Codes: H01S 3/1618 ytterbium
• CPC Class Codes: H01S 3/1623 chromium, e.g. Alexandrite
• CPC Class Codes: H01S 3/1643 YAG
• CPC Class Codes: H01S 3/1673 YVO4 [YVO]

Abstract

Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with the capability of switching between a modelocked pulse operating mode and an amplification operating mode. The operating modes are carried out through the application of a time-dependent bias voltage, having waveforms as described herein, to an electro-optical device positioned along the optical axis of the resonator.

Claims

1. A method for shifting a wavelength of a subnanosecond pulse laser apparatus comprising:

providing a subnanosecond pulse as a pump for a laser resonator with a short roundtrip time, the laser resonator comprising an optical element, the laser resonator having a laser resonator length, wherein the optical element is a laser crystal with high absorption coefficient at the wavelength of the subnanosecond pulse, the laser crystal having a crystal length, wherein the crystal length is equal to the laser resonator length, wherein the roundtrip time of the laser resonator is substantially shorter than a pulse duration of the subnanosecond pulse that was used to pump the laser resonator; and

generating, in the laser resonator, a subnanosecond wavelength shifted pulse having at least about 100 mj/pulse energy with a pulse duration such that a shorter subnanosecond pumping pulse used to pump the laser resonator results in a shorter generated subnanosecond pulse.

2. The method of claim 1, wherein the wavelength shifted pulse is shifted to match an absorption spectrum of a pigment.

3. The method of claim 2 wherein the pigment is at least one of endogenous skin pigment and exogenous tattoo pigment.

4. The method of claim 1 wherein the roundtrip time of the laser resonator is at least 20 times shorter than the wavelength shifted pulse duration.

5. The method of claim 1 wherein the roundtrip time of the laser resonator is at least 13 times shorter than the wavelength shifted pulse duration.

6. The method of claim 1 wherein the roundtrip time of the laser resonator is at least 5 times shorter than the wavelength shifted pulse duration.

7. The method of claim 1 wherein the laser crystal is a rare earth doped laser crystal.

8. The method of claim 1 wherein the laser crystal is one of Nd:

YAG and Nd;

YVO4.

20. The method of claim 1 wherein a second harmonic conversion of the wavelength shifted pulse has a 50 mj/pulse energy.

21. The method of claim 1, wherein the laser resonator has a laser crystal with high absorption coefficient at the wavelength of the subnanosecond pulse.

22. The method of claim 1, wherein the laser resonator has a doped glass with high absorption coefficient at the wavelength of the subnanosecond pulse.

9. An apparatus for shifting a wavelength of a subnanosecond pulse laser comprising

a laser resonator having a laser resonator length, wherein roundtrip time of light in laser resonator is substantially shorter than a pulse duration of a subnanosecond pulse that is used to pump the laser resonator;

and

a laser crystal with a high absorption coefficient at a wavelength of the subnanosecond pulse, wherein laser crystal has a crystal length, wherein the crystal length and the laser resonator length are equal,

the laser crystal disposed in the laser resonator,

the laser resonator being capable of generating a subnanosecond wavelength shifted pulse having at least about 100 mj/pulse energy with a pulse duration such that a shorter subnanosecond pumping pulse used to pump the laser resonator results in a shorter generated subnanosecond pulse.

10. The apparatus of claim 9 wherein the roundtrip time of the laser resonator is at least 20 times shorter than the subnanosecond pulse duration.

11. The apparatus of claim 9 wherein the roundtrip time of the laser resonator is at least 13 times shorter than the subnanosecond pulse duration.

12. The apparatus of claim 9 wherein the roundtrip time of the laser resonator is at least 5 times shorter than the subnanosecond pulse duration.

13. The apparatus of claim 9 wherein the laser crystal is a rare earth doped laser crystal.

14. The apparatus of claim 9 wherein the laser crystal is one of Nd:

YAG and Nd;

YVO4.

15. The apparatus of claim 9 comprising a frequency doubling crystal that generates a second harmonic conversion of the wavelength generated in the laser resonator.

16. The apparatus of claim 15 wherein the second harmonic conversion of the wavelength of the subnanosecond pulse laser matches the absorption spectrum of a pigment.

17. The apparatus of claim 15 wherein the frequency doubling crystal is KTP crystal.

18. The apparatus of claim 9 wherein an additional polarizing element is used with the laser crystal or the doped glass in the laser resonator.

19. The apparatus of claim 9 wherein a second harmonic conversion of the wavelength shifted pulse has a 50 mj/pulse energy.

23. The device of claim 9, wherein the laser resonator has a laser crystal with high absorption coefficient at the wavelength of the subnanosecond pulse.

24. The device of claim 9, wherein the laser resonator has a doped glass with high absorption coefficient at the wavelength of the subnanosecond pulse.