Hybrid charged particle / X-ray-imaging / treatment apparatus and method of use thereof

• US 9,782,140 B2
• Filed: 09/06/2016
• Issued: 10/10/2017
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: ProTom International Holding Corporation
• Original Assignee: Daniel J. Raymond, Lee W. Davis, Susan L. Michaud
• Inventors: Michaud, Susan L., Raymond, Daniel J., Lee, W. Davis
• Primary Examiner(s): MCCORMACK, JASON L
• Application Number:
  US15/257,686
• Publication Number:
  US 20160367207A1
• Time in Patent Office: 399 Days
• Field of Search: 2504923, 2504921, 250306, 378 21, 378 62, 378 63, 378 65
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/0487 Motor-assisted positioning
• CPC Class Codes: A61B 6/4092 for producing synchrotron radiation
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/4266 characterised by using a plurality of detector units A61B6/4014 takes precedence
• CPC Class Codes: A61B 6/50 specially adapted for specific body parts; specially adapted for specific clinical applications
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61N 2005/1054 using a portal imaging system
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 2005/1097 Means for immobilizing the patient
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1044 with multiple repetitions of the scanning pattern
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1069 Target adjustment, e.g. moving the patient support
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes
• CPC Class Codes: G21K 1/08 Deviation, concentration or focusing of the beam by electric or magnetic means electron-optical arrangements in electric discharge tubes H01J29/46; details, e.g. electric or magnetic deviating means for direct voltage accelerators or in accelerators using single pulses H05H5/02; arrangements for injecting particles into orbits H05H7/08; arrangements for ejecting particles from orbits H05H7/10
• CPC Class Codes: G21K 1/10 : Scattering devices; Absorbing devices; Ionising radiation filters
• CPC Class Codes: G21K 5/04 : with beam-forming means

Abstract

The invention comprises a method and apparatus for imaging and treating a tumor of a patient using positively charged particles and X-rays. A mounting rail, supporting a scintillation detection system element and an X-ray detection system element, is alternatingly extended/retracted to position the required detection system element opposite a patient tumor position from an exit nozzle of a beam transport system connected to an accelerator of the positively charged particles, where the positively charged particles are alternatingly used to treat the tumor via irradiation. The mounting rail optionally rotates with rotation of the exit nozzle about the patient, such as with rotation of a support gantry.

Claims

1. A method for imaging a tumor of a patient using positively charged particles and X-rays, comprising the steps of:

sequentially transporting the positively charged particles from an accelerator, through a beam transport line, and through an exit nozzle, to a patient position, said beam transport line comprising;

a positively charged particle beam path; and

an X-ray beam path;

detecting scintillation induced by the positively charged particles using a scintillation detector system;

detecting X-rays using an X-ray detector system;

positioning a mounting rail through linear extension/retraction to;

(1) at a first time and at a first extension position of said mounting rail, position said scintillation detector system opposite the patient position from said exit nozzle and (2) at a second time and at a second extension position of said mounting rail, position said X-ray detector system opposite the patient position from said exit nozzle; and

generating an image of the tumor using output of said scintillation detector system and said X-ray detector system.

2. The method of claim 1, further comprising the steps of:

alternating between said step of detecting scintillation and treating the tumor via irradiation of the tumor using the positively charged particles.

3. The method of claim 2, further comprising the steps of:

providing a rotatable section of said beam transport line, said rotatable section terminating at the exit nozzle; and

a rotatable gantry support co-rotating, about a rotation axis, said rotatable section of said beam transport line, said mounting rail, said positively charged particle beam path, said scintillation detector system, said X-ray beam path, and said X-ray detector system.

5. The method of claim 3, further comprising the steps of:

extending to a first extension position a first side rail supporting a source system element of a secondary imaging system;

extending to said first extension position a second side rail supporting a detector system element of said secondary imaging system; and

a rotatable support circumferentially rotating;

(1) said source element supported by said first side rail about the tumor and (2) said detector system element supported by said second side rail about the tumor, the tumor positioned along a center longitudinal axis of said rotatable support between said first side rail and said second side rail.

6. The method of claim 5, further comprising the step of:

rotating said rotatable support, supporting said first side rail and said second side rail, independent of rotation of said rotatable gantry support.

7. The method of claim 6, further comprising the step of:

at each of at least four circumferential positions of the first side rail and the second side rail about the tumor, imaging the tumor of the patient using both the X-rays and the positively charged particles.

8. The method of claim 7, further comprising the step of:

using tomographic reconstruction to generate a three dimensional image of the tumor using output of said scintillation detector system and said X-ray detector system.

9. The method of claim 1, further comprising the step of:

vertically translating a detector system element of a secondary imaging system past the tumor as a function of time; and

imaging at least one of;

(1) the tumor and (2) an effect of the positively charged particle beam using said detector element.

10. The method of claim 9, said detector element comprising an element of a positron emission tomography system.

11. The method of claim 9, said detector element system comprising a digital X-ray detection system.

4. The method of 3, further comprising the step of:

maintaining said rotation axis orthogonal to said positive charged beam path at both;

(1) a first rotation position of said rotatable gantry support and (2) a second rotation position of said rotatable gantry support rotated at least forty-five degrees from said first rotation position.

12. An apparatus for imaging a tumor of a patient using positively charged particles and X-rays, comprising:

a beam transport line sequentially transporting the positively charged particles from an accelerator, through the beam transport line, and through an exit nozzle, to a patient position, said beam transport line comprising;

a positively charged particle beam path; and

an X-ray beam path;

a scintillation detector system configured to detect scintillation induced by the positively charged particles during use;

an X-ray detector system configured to detect the X-rays during use;

a linearly extendable and retractable mounting rail configured to;

(1) at a first time and at a first extension position of said mounting rail, position said scintillation detector system opposite the patient position from said exit nozzle and (2) at a second time and at a second extension position of said mounting rail, position said X-ray detector system opposite the patient position from said exit nozzle, said apparatus configured to, during use, generate an image of the tumor using output of said scintillation detector system and said X-ray detector system.

13. The apparatus of claim 12, further comprising:

a rotatable section of said beam transport line, said rotatable section terminating at the exit nozzle; and

a rotatable gantry support configured to co-rotate, about a rotation axis, said rotatable section of said beam transport line, said mounting rail, said positively charged particle beam path, said scintillation detector system, said X-ray beam path, and said X-ray detector system.

14. The apparatus of claim 13, said rotation axis orthogonal to said positive charged beam path at both:

(1) a first rotation position of said rotatable gantry support and (2) a second rotation position of said rotatable gantry support.

15. The apparatus of claim 13, further comprising:

an alternatingly extendable and retractable first side rail attached to said rotatable gantry support;

an alternatingly extendable and retractable second side rail attached to a rotationally opposite side of said rotatable gantry support from said first side rail;

a secondary imaging system, comprising;

a first element of an imaging source system attached to said first side rail;

a second element of an imaging detector system attached to said second side rail; and

said rotatable gantry support configured to circumferentially rotate said first element and said second element around the patient during use at a first extension position of said first side rail and said second side rail.

16. The apparatus of claim 15, further comprising:

a vertically translatable support;

a detector system element of a secondary imaging system connected to said translatable support, said vertically translatable support configured to move said detector system element.

17. The apparatus of claim 16, said detector element comprising an element of a positron emission tomography system.

18. The apparatus of claim 14, said scintillation detector system further comprising:

a scintillator material;

a first imaging photon detector array optically coupled to a first side of said scintillator material; and

a second imaging photon detector array optically coupled to a second side of said scintillator material, wherein a first plane of said first side and a second plane of said second side form an angle of greater than thirty degrees.

19. The apparatus of claim 14, further comprising:

an ion beam source coupled to said accelerator; and

a triode extraction system, said triode extraction system comprising a suppression electrode, variable in electrical potential, between said ion beam source and an extraction electrode.

20. A method for imaging a sample using positively charged particles and X-rays, comprising the steps of:

sequentially transporting the positively charged particles from an accelerator, through a beam transport line, and through an exit nozzle, to a patient position, said beam transport line comprising;

a positively charged particle beam path; and

an X-ray beam path;

detecting scintillation induced by the positively charged particles using a scintillation detector system;

detecting X-rays using an X-ray detector system;

positioning a mounting rail through linear extension/retraction to;

(1) at a first time and at a first extension position of said mounting rail, position said scintillation detector system opposite the sample position from said exit nozzle and (2) at a second time and at a second extension position of said mounting rail, position said X-ray detector system opposite the sample position from said exit nozzle; and

generating an image of the sample using output of said scintillation detector system and said X-ray detector system.