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Levothyroxine liquid formulations

DC
  • US 9,782,376 B1
  • Filed: 12/01/2016
  • Issued: 10/10/2017
  • Est. Priority Date: 12/01/2016
  • Status: Active Grant
First Claim
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1. A liquid formulation comprisinglevothyroxine or a pharmaceutically acceptable salt thereof;

  • about 1 mg/mL to about 50 mg/mL of tromethamine;

    about 10 mcg/mL to about 500 mcg/mL of sodium iodide; and

    water;

    wherein the formulation has a pH of about 9.0 to about 11.5, and wherein the formulation is stable for at least 12 months at 25±



    C.

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