Methods for injecting a drug into prostate tissue

• US 9,782,547 B2
• Filed: 01/17/2014
• Issued: 10/10/2017
• Est. Priority Date: 10/12/2001
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Hauschild, Sidney F., Bolea, Stephen L., Neisz, Johann J.
• Primary Examiner(s): Bosques, Edelmira
• Application Number:
  US14/158,507
• Publication Number:
  US 20140135733A1
• Time in Patent Office: 1,362 Days
• Field of Search: 604500
• CPC Class Codes: A61B 17/32037 for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
• CPC Class Codes: A61B 17/3403 Needle locating or guiding means guides for suture needles A61B17/0482; guiding or tracking by nuclear magnetic resonance G01R33/285
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2017/003 Steerable
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2017/2946 Locking means
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2090/035 preventing further rotation
• CPC Class Codes: A61B 2090/0801 Prevention of accidental cutting or pricking
• CPC Class Codes: A61M 5/3007 with specially designed jet passages at the injector's distal end
• CPC Class Codes: A61M 5/3287 Accessories for bringing the needle into the body; Automatic needle insertion A61M5/20, A61M5/31525 take precedence
• CPC Class Codes: A61M 5/486 Indicating injection pressure
• CPC Class Codes: A61M 5/488 Limiting injection pressure

Abstract

Method and surgical instrument for treating prostate tissue including a surgical instrument having a main body, a needle deployment port, a needle, first and second handles and a lockout release mechanism to limit needle extension. Additionally, a kit includes the surgical instrument, together with a cystoscope, and optionally a syringe and reservoir of ethanol. The method includes needle-less injection and visualizing the ethanol injection by delivering both an echogenic agent and ethanol either by needle or needle-less injection or by providing an ultrasonically visible marker near the tip of the ethanol delivery cannula. The method also includes extending the needle transversely of the instrument housing using a link assembly.

Claims

1. A method comprising:

positioning a housing adjacent an injection site, the housing comprising a link assembly, a pusher, and a needle, wherein a first link arm of the link assembly is pivotally connected to the housing and a single pivot on the needle, and a second link arm of the link assembly is pivotally connected to the pusher and the single pivot on the needle, such that the first and second link arms are pivotally connected to each other at the single pivot point, and the needle is extendable between (i) a retracted position at which a distal end of the needle is located within the housing, and (ii) an extended position at which the distal end of the needle is located outside the housing;

moving the pusher longitudinally in the housing to raise the needle into the extended position by pivoting the second link arm about the single pivot point until the distal end of the needle penetrates the injection site; and

injecting a substance into the injection site through a lumen of the needle.

2. The method of claim 1, wherein the step of extending the needle further comprises pivoting the link assembly about a pivot on the housing.

3. The method of claim 2, wherein the first link arm is pivotally connected to the pivot on the housing, and wherein the step of extending the needle further comprises pivoting the needle using at least one of the first and second link arms.

4. The method of claim 1, wherein the step of extending the needle further comprises moving the needle using a slot moving along a pin connected to the housing.

5. The method of claim 1, wherein the step of extending the needle further comprises guiding the needle through a slot in the housing.

6. The method of claim 1, wherein the second link arm is pivotally connected to a pivot on the pusher, and wherein the step of extending the needle further comprises pivoting the needle by application of a longitudinal force to the pusher.

7. The method of claim 1, wherein the step of extending the needle further comprises extending the needle out of a needle deployment port in the housing.

8. The method of claim 7, wherein the step of positioning the housing comprises placing the needle deployment port adjacent the injection site.

9. The method of claim 1, wherein the extending the needle comprises moving the pusher to incrementally extend the needle from the housing.

10. The method of claim 1, further comprising projecting a light onto the patient at a location coinciding with an injection point for the distal end of the needle.

11. The method of claim 1, wherein the housing includes an ultrasonic transducer on or near the needle, and the method further comprises:

dispersing the injected substance in the injection site using the ultrasound transducer.

12. A method of operating a surgical instrument having a housing including a link assembly, a pusher, and a needle including a lumen, wherein the link assembly includes a first link arm and a second link arm, the first link arm being pivotally connected to the housing and a single pivot on the needle, and the second link arm being pivotally connected to the pusher and the single pivot on the needle, such that the first and second link arms are pivotally connected to each other at the single pivot point, the method comprising:

positioning the housing adjacent an injection site;

moving the pusher longitudinally in the housing to raise the needle by pivoting the second link arm about the single pivot point until a distal end of the needle extends generally transversely from;

(i) a retracted position inside the housing at which the distal end of needle does not contact the injection site, to (ii) an extended position outside the housing at which the distal end of the need penetrates the injection site; and

moving a substance into the injection site through the lumen of the needle.

13. The method of claim 12, wherein the step of moving the pusher further comprises pivoting the link assembly about a pivot on the housing.

14. The method of claim 12, wherein the first link arm is pivotally connected to a pivot on the housing, and wherein the step of moving the pusher further comprises pivoting the link assembly about the pivot on the housing.

15. The method of claim 14, wherein the second link arm is pivotally connected to the pivot on the pusher, and wherein the step of moving the pusher further comprises pivoting the needle by application of a longitudinal force to the pusher.

16. A surgical instrument, the instrument comprising:

a housing comprising a pusher, a needle including a lumen for injecting a substance into an injection site, and a link assembly including a first link arm and a second link arm, the first link arm being pivotally connected to the housing and a single pivot point on the needle, and the second link arm being pivotally connected to the pusher and the single pivot, such that the first and second link arms are pivotally connected to each other at the single pivot point, wherein moving the pusher longitudinally in the housing raises the needle by pivoting the second link arm about the single pivot point until a distal end of the needle extends generally transversely from (i) a retracted position inside the housing to (ii) an extended position outside the housing.

17. The instrument of claim 16, wherein the first link arm is pivotally connected to a pivot point on the housing.

18. The instrument of claim 16, wherein the single pivot point on the needle includes one or more trunnions.

19. The instrument of claim 16, further comprising a slot on the distal end of the housing, wherein the needle extends generally transversely out of the slot.