Minimally invasive lung volume reduction devices, methods, and systems

• US 9,782,558 B2
• Filed: 08/06/2014
• Issued: 10/10/2017
• Est. Priority Date: 03/13/2006
• Status: Expired due to Fees

• Current Assignee: Ekos LLC (Boston Scientific Corporation)
• Original Assignee: PneumRx, Inc. (Boston Scientific Corporation)
• Inventors: Aronson, Nathan, Wu, Patrick, Lehrberg, David, Mathis, Mark L.
• Primary Examiner(s): ANDERSON, GREGORY A
• Application Number:
  US14/453,372
• Publication Number:
  US 20150080934A1
• Time in Patent Office: 1,161 Days
• CPC Class Codes: A61B 1/044 for absorption imaging
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2017/00867 shape memory effect
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/485 involving fluorescence X-ray imaging
• CPC Class Codes: A61B 90/00 Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges protective face masks A41D13/11; surgeon's or patient's gowns or dresses A41D13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M1/00
• CPC Class Codes: A61B 90/02 Devices for expanding tissue, e.g. skin tissue implements for holding wounds open, surgical tractors A61B17/02; implantable mammary prosthesis A61F2/12; dilators A61M29/00
• CPC Class Codes: A61F 2002/043 : Bronchi
• CPC Class Codes: A61F 2002/046 : Tracheae
• CPC Class Codes: A61M 16/04 : Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0406 : implanted flow modifiers
• CPC Class Codes: A61M 16/0833 : T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 16/208 : Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2205/0266 : Shape memory materials
• CPC Class Codes: A61M 2205/32 : with radio-opaque indicia
• CPC Class Codes: A61M 37/0069 : Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

Claims

1. A system for treating a patient having a lung with an airway, the system comprising:

a lung implant having an elongate length with a proximal and distal end for deployment within the airway of the patient, the lung implant transitionable between a delivery configuration and a deployed configuration, the deployed configuration configured to impart a force on the airway sufficient to bend an axis of the airway so as to locally compress lung tissue;

a delivery catheter with a lumen for delivering the lung implant to the airway of the lung; and

a loading cartridge comprising a lumen and configured to contain the lung implant for delivery into the delivery catheter, the loading cartridge constraining the implant to the delivery configuration and the lung implant configured to elastically recover toward a bent configuration to impart the force on the airway that bends the axis of the airway into a folded configuration; and

a grasper configured to couple with a proximal portion of the lung implant to pull the lung implant into the loading cartridge and to push the lung implant from the loading cartridge into the delivery catheter for delivery into the airway.

2. The system of claim 1, wherein the loading cartridge is configured to couple with a proximal end of the delivery catheter so that the lumen of the loading cartridge and the lumen of the delivery catheter form a continuous lumen.

3. The system of claim 2, wherein the loading cartridge is configured to couple to the proximal end of the delivery catheter via a locking hub connection.

4. The system of claim 3, wherein the locking hub connection comprises a luer lock hub.

5. The system of claim 1, wherein the grasper comprises a set of jaws for releasably locking onto the proximal portion of the lung implant.

6. The system of claim 1, further comprising a bronchoscope with a working channel and wherein the delivery catheter is configured to deliver the lung implant to the airway through the working channel of the bronchoscope.

7. The system of claim 6, further comprising an x-ray guidance system for imaging a position of the lung implant within the lung.

8. The system of claim 1, wherein the loading cartridge is terminated with an open end.

9. The system of claim 1, wherein the loading cartridge is terminated with a hub.

10. The system of claim 1, wherein the loading cartridge constrains the lung implant to a diameter that is equal to or less than 18 mm.

11. The system of claim 1, wherein the lung implant is disposed within the loading cartridge.

12. The system of claim 1, further comprising an actuation plunger.

13. The system of claim 12, wherein the actuation plunger is operable to lock the grasper to the lung implant.

14. The system of claim 12, wherein the actuation plunger is operable to release the lung implant from the grasper.

15. A method of treating a patient having a lung with an airway, the method comprising:

positioning a distal end of a delivery catheter to the airway of the lung;

coupling a distal end of a loading cartridge to a proximal end of the delivery catheter so that a lumen of the loading cartridge and a lumen of the delivery catheter form a continuous lumen, and

loading the lung implant in the loading cartridge prior to coupling the loading cartridge to the delivery catheter, wherein the loading of the lung implant comprises coupling the lung implant with a grasper and pulling the lung implant into the lumen of the loading cartridge with the grasper;

pushing a lung implant loaded within the loading cartridge from within the lumen of the loading cartridge to the lumen of the delivery catheter;

delivering the lung implant in a delivery configuration to the distal end of the delivery catheter;

deploying the lung implant to a deployed configuration within the airway of the lung from the delivery configuration in the distal end of the delivery catheter; and

wherein the pushing of the lung implant from the loading cartridge into the lumen of the delivery catheter comprises grasping a proximal portion of the lung implant with the grasper and pushing the lung implant into the lumen of the delivery catheter with the grasper;

wherein the deployed configuration of the lung implant within the airway bends the airway of the lung so as to locally compress lung tissue.

16. The method of claim 15, further comprising receiving the loading cartridge with the lung implant constrained therein and with a distal end of the loading cartridge sealed.

17. The method of claim 16, further comprising unsealing the distal end of the loading cartridge prior to coupling the distal end of the loading cartridge with the proximal end of the delivery catheter.

18. The method of claim 15, wherein the step of coupling the lung implant with the grasper comprises using an actuation plunger.

19. The method of claim 15, further comprising releasing the lung implant from the grasper using an actuation plunger.