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Glucagon superfamily peptides exhibiting nuclear hormone receptor activity

  • US 9,783,592 B2
  • Filed: 07/24/2015
  • Issued: 10/10/2017
  • Est. Priority Date: 05/13/2010
  • Status: Expired due to Fees
First Claim
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1. A compound comprising the structure Q-L-Y;

  • wherein Q is a glucagon superfamily peptide;

    Y is a steroid, which antagonizes a Type I nuclear hormone receptor (NHR) activity, with an EC50 of about 1μ

    M or less, and has a molecular weight of up to about 1000 daltons; and

    L is a linking group or a bond, with the proviso that Y is not a bile salt or cholesterol.

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