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Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof

  • US 9,783,610 B2
  • Filed: 03/15/2013
  • Issued: 10/10/2017
  • Est. Priority Date: 04/27/2012
  • Status: Active Grant
First Claim
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1. An anti-tumor endothelial marker-1 (TEM-1) antigen-binding fragment dimer comprising two anti-TEM1 antigen-binding fragments, wherein each antigen-binding fragment comprises a single chain variable region and a hinge region, wherein the two antigen-binding fragments are linked through the two hinge regions, wherein said antigen-binding fragments specifically bind an epitope situated between TEM1 amino acids 324 and 390, wherein each monomer further comprises an antibody constant region comprising an Fc region, and wherein said antigen-binding fragment is scFv78-Fc, and the amino acid sequence of said scFv78-Fc comprises the sequence set forth in SEQ ID NO:

  • 44.

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