System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
First Claim
Patent Images
1. An apparatus which is configured to obtain at least one electro-magnetic radiation from at least one portion of a sample, comprising:
- at least one optical first arrangement which is configured to receive the at least one electro-magnetic radiation from the at least one portion, and generate at least one first radiation based on the at least one electro-magnetic radiation, wherein the at least one optical first optical arrangement receives, separates and recombines the at least one electro-magnetic radiation to be self-interfered to generate the first radiation;
at least one interference second arrangement which is configured to receive, separate and recombine the first radiation so as to self-interfere and generate at least one second radiation;
detector elements configured to detect the at least one second radiation; and
at least one computer third arrangement which is configured to determine information regarding the at least one portion based on the detected portions of the at least one second radiation.
1 Assignment
0 Petitions
Accused Products
Abstract
Systems and methods according to exemplary embodiments of the present disclosure can be provided that can efficiently detect the amplitude and phase of a spectral modulation. Such exemplary scheme can be combined with self-interference fluorescence to facilitate a highly sensitive depth localization of self-interfering radiation generated within a sample. The exemplary system and method can facilitate a scan-free depth sensitivity within the focal depth range for microscopy, endoscopy and nanoscopy.
-
Citations
21 Claims
-
1. An apparatus which is configured to obtain at least one electro-magnetic radiation from at least one portion of a sample, comprising:
-
at least one optical first arrangement which is configured to receive the at least one electro-magnetic radiation from the at least one portion, and generate at least one first radiation based on the at least one electro-magnetic radiation, wherein the at least one optical first optical arrangement receives, separates and recombines the at least one electro-magnetic radiation to be self-interfered to generate the first radiation; at least one interference second arrangement which is configured to receive, separate and recombine the first radiation so as to self-interfere and generate at least one second radiation; detector elements configured to detect the at least one second radiation; and at least one computer third arrangement which is configured to determine information regarding the at least one portion based on the detected portions of the at least one second radiation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
-
13. A method for obtaining at least one electro-magnetic radiation from at least one portion of a sample, comprising:
-
receiving the at least one electro-magnetic radiation from the at least one portion, and generating at least one first radiation based on the at least one electro-magnetic radiation, wherein the at least one electro-magnetic radiation is separated and recombined with at least one optical arrangement to be self-interfered to generate the first radiation; receiving, separating and recombining the first radiation with at least one interference arrangement so as to further self-interfere and generate at least one second radiation; and with detector elements, detecting portions the at least one second radiation; using at least one computer arrangement, determining information regarding the at least one portion based on the detected portions of the at least one second radiation. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
-
Specification