Voltammetric systems for assaying biological analytes
First Claim
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1. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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electronic circuitry in electrical communication with the contacts, the electronic circuitry comprising;
an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium;
where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, determines the concentration of the analyte in the sample from the current measured from the contacts, the analyte being selected from a group consisting of glucose, cholesterol, triglyceride, lactate, pyruvate, alcohol, bilirubin, uric acid, NAD(P)H, and carbon monoxide;
where the computer readable software code, when executed by the processor, causes the electric charger to apply a voltammetric scan through the contacts, and causes the processor to implement a data treatment to the current measured from the contacts, the data treatment selected from the group consisting of a semi-integral data treatment, a derivative data treatment, a semi-derivative data treatment, and combinations thereof.
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Abstract
The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.
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Citations
25 Claims
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1. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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contacts; and electronic circuitry in electrical communication with the contacts, the electronic circuitry comprising; an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium; where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, determines the concentration of the analyte in the sample from the current measured from the contacts, the analyte being selected from a group consisting of glucose, cholesterol, triglyceride, lactate, pyruvate, alcohol, bilirubin, uric acid, NAD(P)H, and carbon monoxide; where the computer readable software code, when executed by the processor, causes the electric charger to apply a voltammetric scan through the contacts, and causes the processor to implement a data treatment to the current measured from the contacts, the data treatment selected from the group consisting of a semi-integral data treatment, a derivative data treatment, a semi-derivative data treatment, and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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contacts; and electronic circuitry in electrical communication with the contacts; the electronic circuitry comprising an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium; where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, causes the electric charger to apply a voltammetric forward linear scan through the contacts and the processor to determine the concentration of the analyte in the sample from the current measured from the contacts, the analyte being selected from a group consisting of glucose, cholesterol, triglycerides, lactate, pyruvate, alcohol, bilirubin, uric acid, NAD(P)H, and carbon monoxide. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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contacts; and electronic circuitry in electrical communication with the contacts, the electronic circuitry comprising; an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium; where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, determines the concentration of the analyte in the sample from the current measured from the contacts; where the computer readable software code, when executed by the processor, causes the electric charger to apply a voltammetric scan through the contacts, and causes the processor to implement a data treatment to the current measured from the contacts, the data treatment comprising a semi-integral data treatment that separates at least one steady-state current from at least one hematocrit-affected equilibrium current.
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22. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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contacts; and electronic circuitry in electrical communication with the contacts, the electronic circuitry comprising; an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium; where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, determines the concentration of the analyte in the sample from the current measured from the contacts; where the computer readable software code, when executed by the processor, causes the electric charger to apply a voltammetric scan through the contacts, and causes the processor to implement a data treatment to the current measured from the contacts, the data treatment comprising a semi-integral data treatment and a hematocrit compensation, the hematocrit compensation including determining a ratio of a peak current value to a steady-state current value.
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23. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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contacts; and electronic circuitry in electrical communication with the contacts, the electronic circuitry comprising; an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium; where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, determines the concentration of the analyte in the sample from the current measured from the contacts; where the computer readable software code, when executed by the processor, causes the electric charger to apply a voltammetric scan through the contacts, and causes the processor to implement a data treatment to the current measured from the contacts, the data treatment comprising a hematocrit compensation, the hematocrit compensation including dividing a negative peak by a positive peak.
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24. A measuring device, for determining the concentration of an analyte in a sample, comprising:
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contacts; electronic circuitry in electrical communication with the contacts; the electronic circuitry comprising an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium; and a sensor strip comprising first and second sensor strip contacts in electrical communication with the contacts, the first sensor strip contact in electrical communication with a working electrode and the second sensor strip contact in electrical communication with a counter electrode through conductors, where a first reagent layer is on at least one of the electrodes, the first reagent layer comprising an oxidoreductase and at least one species of a redox pair; where the processor is programmed to measure current from the contacts, and the computer readable storage medium comprises computer readable software code, which when executed by the processor, causes the electric charger to apply a voltammetric forward linear scan through the contacts and the processor to determine the concentration of the analyte in the sample from the current measured from the contacts. - View Dependent Claims (25)
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Specification