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Method and device for detecting and assessing reactive hyperemia using segmental plethysmography

  • US 9,788,733 B2
  • Filed: 03/11/2014
  • Issued: 10/17/2017
  • Est. Priority Date: 06/02/2009
  • Status: Active Grant
First Claim
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1. A method for measuring reactive hyperemia in a subject, comprising:

  • performing a first segmental cuff plethysmography having an inflation phase and a deflation phase and generating a first cuff compliance curve based only on data collected during the deflation phase of the first segmental cuff plethysmography;

    generating a baseline arterial compliance curve and/or a baseline pressure-area (P-A) curve on a portion of the body of the subject, wherein the cuff pressure is increased to a first peak cuff pressure during the inflation phase and immediately reduced from the first peak cuff pressure during the deflation phase;

    performing a second segmental cuff plethysmography having an inflation phase, a holding phase, and a deflation phase and generating a second cuff compliance curve based only on data collected during the deflation phase of the first segmental cuff plethysmography;

    generating a hyperemic arterial compliance curve and/or a hyperemic P-A curve, wherein the cuff pressure is increased to a second peak level during the inflation phase, maintained at the second peak cuff pressure for a predetermined period of time during the holding phase, and then reduced from the second peak cuff pressure during the deflation phase;

    calculating the difference between the baseline arterial compliance curve and the hyperemic arterial compliance curve as an area between the arterial compliance curves, and/or the difference between the baseline P-A curve and the hyperemic P-A curve as an area between the P-A curves; and

    measuring a level of reactive hyperemia based on the area between the arterial compliance curves and/or the area between the P-A curves,wherein said first and second cuff compliance curves are generated using a flowmeter that directly measures the volume change in the cuff during the deflation phase.

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