Continuous monitoring of tumor hypoxia using near-infrared spectroscopy and tomography with a photonic mixer device

• US 9,788,770 B1
• Filed: 04/14/2016
• Issued: 10/17/2017
• Est. Priority Date: 04/14/2016
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Belthangady, Chinmay, Kashif, Faisal, Lee, Seung Ah, Troy, Tamara, Perreault, John D., Alla, Suresh
• Primary Examiner(s): Stafira, Michael P
• Application Number:
  US15/098,686
• Publication Number:
  US 20170296110A1
• Time in Patent Office: 551 Days
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: H04N 23/21 from near infrared [NIR] radiation
• CPC Class Codes: H04N 25/71 Charge-coupled device [CCD] sensors; Charge-transfer registers specially adapted for CCD sensors
• CPC Class Codes: H04N 25/76 Addressed sensors, e.g. MOS or CMOS sensors
• CPC Class Codes: H04N 5/33 Transforming infrared radiation cameras or camera modules for generating image signals from infrared radiation H04N23/20; circuitry of SSIS for transforming infrared radiation into image signals H04N25/20

Abstract

A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.

Claims

1. A device for continuous monitoring of a tumor in a tissue region, the device comprising:

a PMD camera chip; and

at least two amplitude modulated near-infrared light sources horizontally separated from the PMD camera chip such that the PMD camera chip and the at least two near-infrared light sources are in a reflection geometry,

wherein a first amplitude modulated near-infrared light source emits near-infrared light at a first wavelength, the first wavelength below an isosbestic point of hemoglobin, and

wherein a second amplitude modulated near-infrared light source emits near-infrared light at a second wavelength, the second wavelength above the isosbestic point of hemoglobin.

2. The device of claim 1, wherein the PMD camera chip is a multi-pixel PMD camera chip.

3. The device of claim 1, wherein the at least two modulated near-infrared light sources are included in an array of modulated near-infrared light sources arranged around the PMD camera chip.

4. The device of claim 1, wherein each of the at least two modulated near-infrared light sources is modulated at different frequencies.

5. The device of claim 1, further comprising a motor to move the at least two modulated near-infrared light sources around the PMD camera chip.

6. The device of claim 1, further comprising a wireless communication system to transmit recorded data to a remote processing unit or a cloud server.

7. The device of claim 1, further comprising a wireless power system.

8. The device of claim 1, wherein a distance between the modulated near-infrared light sources and the PMD camera chip is approximately twice the depth of the tumor from the surface of the tissue region.