PAR4 inhibitor therapy for patients with PAR4 polymorphism
First Claim
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1. A method of preventing or treating thrombosis in a human subject in need thereof, the method comprising administering a therapeutically effective amount of a PAR4 inhibitor to a human subject determined to have a “
- G”
allele for a single-nucleotide polymorphism (SNP) at rs773902.
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Abstract
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to have a “G” allele for a single-nucleotide polymorphism (SNP) at rs773902, and not administering a PAR4 inhibitor to a subject determined to have an “A” allele for the SNP at rs773902. A genotyping assay can be used to determine the SNP.
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7 Claims
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1. A method of preventing or treating thrombosis in a human subject in need thereof, the method comprising administering a therapeutically effective amount of a PAR4 inhibitor to a human subject determined to have a “
- G”
allele for a single-nucleotide polymorphism (SNP) at rs773902. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- G”
Specification