Dosage regimen, medication dispensing package and uses thereof for the treatment of major depressive disorder
First Claim
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1. A method of treating treatment-refractory depression, comprising:
- administering D-cylcoserine at a dosage of 1000 mg/day-2000 mg/day to a patient under treatment for depression wherein said patient is receiving either an approved antidepressant agent selected from the group consisting of tetracyclic antidepressants (TeCA), selective serotine reuptake inhibitors (SSRIs), and serotonin/norepinephrin reuptake inhibitors (SNRIs), or an antipsychotic agent approved for treatment of depression, wherein said patient is treatment-refractory, and wherein said patient is experiencing side effects from receiving said antidepressant or said antipsychotic agent.
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Abstract
This invention provides an oral dosage regimen for the treatment of depression, a pharmaceutically acceptable medication dispensing package containing multiple dosage units of medicaments comprising an oral dosage regimen of D-cycloserine for the treatment of depression, a pharmaceutical composition comprising D-cycloserine formulated for oral administration providing a dosage of 1000 mg/day alone or in combination with antidepressant agents and uses thereof.
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Citations
12 Claims
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1. A method of treating treatment-refractory depression, comprising:
- administering D-cylcoserine at a dosage of 1000 mg/day-2000 mg/day to a patient under treatment for depression wherein said patient is receiving either an approved antidepressant agent selected from the group consisting of tetracyclic antidepressants (TeCA), selective serotine reuptake inhibitors (SSRIs), and serotonin/norepinephrin reuptake inhibitors (SNRIs), or an antipsychotic agent approved for treatment of depression, wherein said patient is treatment-refractory, and wherein said patient is experiencing side effects from receiving said antidepressant or said antipsychotic agent.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of reducing the side effects of D-cycloserine in a human comprising:
administering D-cylcoserine at a dosage of 1000 mg/day-2000 mg/day together with an effective amount of either an approved antidepressant agent selected from the group consisting of tetracyclic antidepressants (TeCA), selective serotonin reuptake inhibitors (SSRIs), and serotonin/norepinephrin reuptake inhibitors (SNRIs), or an antipsychotic agent approved for treatment of depression to a patient, wherein said patient is refractory to treatment of depression.
Specification