Bone implant and systems that controllably releases silver

• US 9,789,298 B2
• Filed: 06/10/2014
• Issued: 10/17/2017
• Est. Priority Date: 11/12/2010
• Status: Expired due to Fees

• Current Assignee: Silver Bullet Therapeutics, Inc.
• Original Assignee: Silver Bullet Therapeutics, Inc.
• Inventors: Dehnad, Houdin, Chopko, Bohdan Wolodymyr, Chirico, Paul E., McCormick, Robert Vincent
• Primary Examiner(s): WOODALL, NICHOLAS W
• Application Number:
  US14/300,696
• Publication Number:
  US 20140288607A1
• Time in Patent Office: 1,225 Days
• CPC Class Codes: A61B 17/686 Plugs, i.e. elements forming interface between bone hole and implant or fastener, e.g. screw
• CPC Class Codes: A61B 17/7266 with fingers moving radially outwardly
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/8625 Shanks, i.e. parts contacting bone tissue
• CPC Class Codes: A61B 17/863 with thread interrupted or changing its form along shank, other than constant taper
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/8685 comprising multiple separate parts
• CPC Class Codes: A61B 17/869 characterised by an open form, e.g. wire helix
• CPC Class Codes: A61B 2017/00889 antimicrobial, disinfectant
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61C 19/06 Implements for therapeutic treatment radiation therapy A61N5/00
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61C 8/0018 characterised by the shape
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body

Abstract

Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.

Claims

1. An implant for providing antimicrobial treatment to a bone, tissue or organ, the implant comprising:

an elongate body having a threaded outer screw region;

an inner channel within the elongate body;

a plurality of exit channels extending from the inner channel and out through the elongate body; and

a treatment cartridge configured to mate with the inner channel and comprising a plurality release members, each release member configured to extend from the cartridge body out through an exit channel and to galvanically release silver, zinc, or silver and zinc, wherein the treatment cartridge is configured to retract the release members into the cartridge body.

2. The implant of claim 1, wherein the treatment cartridge has a helical region.

3. The implant of claim 1, wherein the treatment cartridge degrades as the silver, zinc, or silver and zinc is released.

4. The implant of claim 1, wherein the treatment cartridge comprises a guide to aid in aligning the treatment cartridge within the elongate body.

5. The implant of claim 1, wherein the treatment cartridge is configured to engage with an insertion tool for insertion into the inner channel.

6. The implant of claim 1, wherein the elongate body comprises a coating of silver, zinc or silver and zinc adapted to be galvanically released.

7. The implant of claim 1, wherein the release members comprise a coating of silver, zinc or silver and zinc adapted to be galvanically released.

8. An implant for providing antimicrobial treatment to a bone, tissue or organ, the implant comprising:

an elongate body having a threaded outer screw region and a sharp distal end;

a first coating forming a band around the threaded outer screw region of one or more of platinum, palladium and gold; and

a second coating of one or more of silver, zinc, or silver and zinc, wherein the second coating contacts the first coating and is configured to corrode when the implant is inserted into the bone, tissue or organ and galvanically release one or more of silver, zinc or silver and zinc as the second coating is corroded in the presence of an electrolytic solution;

a treatment cartridge configured to engage an inner chamber within the elongate body, wherein the second coating is on the treatment cartridge, wherein the treatment cartridge comprises a guide to aid in aligning the treatment cartridge within the elongate body.

9. The implant of claim 8, wherein the treatment cartridge degrades as the silver, zinc, or silver and zinc is released.

10. The implant of claim 8, wherein the treatment cartridge is configured to extend release members out of the cartridge body.

11. The implant of claim 8, wherein the treatment cartridge is configured to engage with an insertion tool for insertion into the inner channel.

12. An implant for providing antimicrobial treatment to a bone, tissue or organ, the implant comprising:

an elongate body having a threaded outer screw region;

an inner channel within the elongate body;

a plurality of exit channels extending from the inner channel and out through the elongate body; and

a treatment cartridge configured to mate with the inner channel and comprising a plurality release members, each release member configured to extend from the cartridge body out through an exit channel and to galvanically release silver, zinc, or silver and zinc, wherein the treatment cartridge comprises a guide to aid in aligning the treatment cartridge within the elongate body.

13. The implant of claim 12, wherein the treatment cartridge has a helical region.

14. The implant of claim 12, wherein the treatment cartridge degrades as the silver, zinc, or silver and zinc is released.

15. The implant of claim 12, wherein the treatment cartridge comprises a guide to aid in aligning the treatment cartridge within the elongate body.

16. The implant of claim 12, wherein the treatment cartridge is configured to engage with an insertion tool for insertion into the inner channel.

17. The implant of claim 12, wherein the elongate body comprises a coating of silver, zinc or silver and zinc adapted to be galvanically released.

18. The implant of claim 12, wherein the release members comprise a coating of silver, zinc or silver and zinc adapted to be galvanically released.