Dual prophylactic and abortive electrical stimulation

• US 9,789,307 B2
• Filed: 04/26/2012
• Issued: 10/17/2017
• Est. Priority Date: 04/29/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gerber, Martin T., Goetz, Steven M., Poletto, Christopher
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Piateski, Erin M
• Application Number:
  US13/456,969
• Publication Number:
  US 20120277823A1
• Time in Patent Office: 2,000 Days
• Field of Search: 607 46
• CPC Class Codes: A61N 1/36 for stimulation
• CPC Class Codes: A61N 1/36057 adapted for stimulating afferent nerves
• CPC Class Codes: A61N 1/36075 Headache or migraine
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36132 using patient feedback

Abstract

Prophylactic stimulation and abortive electrical stimulation are delivered to a cranial nerve, including, e.g. an occipital or trigeminal nerve to treat symptoms of various conditions, including, e.g. occipital neuralgia or migraines.

Claims

1. A method comprising:

delivering prophylactic electrical stimulation to a cranial nerve at a first stimulation intensity within a first range of stimulation intensity thresholds determined based on patient perception in the absence of any symptoms of a chronic condition, wherein the prophylactic stimulation is configured to inhibit onset of a symptom of the chronic condition; and

delivering abortive electrical stimulation to the cranial nerve at a second stimulation intensity within a second range of stimulation intensity thresholds determined based on patient perception while a symptom of the chronic condition is occurring, wherein the abortive stimulation is configured to reduce an effect of a symptom of the chronic condition.

2. The method of claim 1, wherein the first range of stimulation intensity thresholds comprises a range from a first low stimulation intensity threshold determined based on patient perception to a first high stimulation intensity threshold determined based on patient perception, and wherein the first low stimulation intensity threshold comprises at least one of a first perception threshold or a first paresthesia threshold and the first high stimulation threshold comprises at least one of a first muscle recruitment threshold, a first discomfort threshold, or a first pain threshold.

3. The method of claim 2, wherein the second range of stimulation intensity thresholds comprises a range from a second low stimulation intensity threshold determined based on patient perception to a second high stimulation intensity threshold determined based on patient perception, and wherein the second low stimulation intensity threshold comprises at least one of a second perception threshold or a second paresthesia threshold and the second high stimulation intensity threshold comprises at least one of a second muscle recruitment threshold, a second discomfort threshold, or a second pain threshold.

4. The method of claim 1, wherein delivering the abortive stimulation comprises reducing a stimulation intensity of the prophylactic stimulation from a stimulation intensity within the first range of stimulation intensity thresholds to a stimulation intensity within the second range of stimulation intensity thresholds.

5. The method of claim 1, wherein delivering the abortive stimulation comprises:

delivering a first abortive stimulation after onset of a symptom of the chronic condition is anticipated; and

delivering a second abortive stimulation while the symptom of the chronic condition is occurring.

6. The method of claim 5, wherein delivering the second abortive stimulation comprises delivering the second abortive stimulation after an intensity level of the symptom has increased above a level during the onset of the symptom.

7. The method of claim 1, further comprising anticipating onset of a symptom of the chronic condition.

8. The method of claim 7, wherein the abortive stimulation is delivered in response to anticipating the onset of the symptom of the chronic condition.

9. The method of claim 1, wherein the first range of stimulation intensity thresholds is different than the second range of stimulation intensity thresholds.

10. The method of claim 1, wherein the first stimulation intensity is greater than the second stimulation intensity.

11. The method of claim 1, wherein the chronic condition is one of migraine headaches, occipital neuralgia or trigeminal neuralgia.

12. The method of claim 1 further comprising:

receiving an indication from the patient of anticipation of the onset of a symptom of the chronic condition; and

in response to receiving the indication, delivering the abortive electrical stimulation.

13. A system comprising:

an implantable electrical stimulation generator; and

a processor configured to control the stimulation generator to deliver prophylactic electrical stimulation to a cranial nerve at a first stimulation intensity within a first range of stimulation intensity thresholds determined based on patient perception in the absence of any symptoms of a chronic condition, and to deliver abortive electrical stimulation to the cranial nerve at a second stimulation intensity within a second range of stimulation intensity thresholds based on patient perception while a symptom of the chronic condition is occurring,

wherein the prophylactic stimulation is configured to inhibit onset of a symptom of the chronic condition, and

wherein the abortive stimulation is configured to reduce an effect of a symptom of the chronic condition.

14. The system of claim 13, wherein the first range of stimulation intensity thresholds comprises a range from a first low stimulation intensity threshold determined based on patient perception to a first high stimulation intensity threshold determined based on patient perception, and wherein the first low stimulation intensity threshold comprises at least one of a first perception threshold or a first paresthesia threshold and the first high stimulation intensity threshold comprises at least one of a first muscle recruitment threshold, a first discomfort threshold, or a first pain threshold.

15. The system of claim 14, wherein the second range of stimulation intensity thresholds comprises a range from a second low stimulation intensity threshold determined based on patient perception to a second high stimulation intensity threshold determined based on patient perception, and wherein the second low stimulation intensity threshold comprises at least one of a second perception threshold or a second paresthesia threshold and the second high stimulation intensity threshold comprises at least one of a second muscle recruitment threshold, a second discomfort threshold, or a second pain threshold.

16. The system of claim 13, wherein the processor is configured to control the stimulation generator to deliver the abortive stimulation at least by reducing a stimulation intensity of the prophylactic stimulation from within the first range of stimulation intensity thresholds to within the second range of stimulation intensity thresholds.

17. The system of claim 13, wherein the processor is configured to control the stimulation generator to deliver a first abortive stimulation after onset of a symptom of the chronic condition is anticipated and deliver a second abortive stimulation while the symptom of the chronic condition is occurring.

18. The system of claim 17, wherein the processor is configured to control the stimulation generator to deliver the second abortive stimulation after an intensity level of the symptom has increased above a level during the onset of the symptom.

19. The system of claim 13, wherein the processor is configured to receive an indication of anticipating onset of a symptom of the chronic condition.

20. The system of claim 19, wherein the processor is configured to control the stimulation generator to deliver the abortive stimulation in response to receiving the indication of anticipating the onset of the symptom of the chronic condition.

21. The system of claim 13, wherein the implantable electrical stimulation generator and the processor reside within a housing of an implantable medical device.

22. The system of claim 13, further comprising an external programmer comprising the processor.

23. The system of claim 13, wherein the first range of stimulation intensity thresholds is different than the second range of stimulation intensity thresholds.

24. The system of claim 13, wherein the first stimulation intensity is greater than the second stimulation intensity.

25. The system of claim 13, wherein the chronic condition is one of migraine headaches, occipital neuralgia or trigeminal neuralgia.

26. The system of claim 13, wherein the processor is further configured to deliver the abortive electrical stimulation in response to receiving an indication from the patient of anticipation of the onset of a symptom of the chronic condition.

27. A computer-readable storage medium comprising instructions for causing a programmable processor to:

deliver prophylactic electrical stimulation to a cranial nerve at a first stimulation intensity within a first range of stimulation intensity thresholds determined based on patient perception in the absence of any symptoms of a chronic condition, wherein the prophylactic stimulation is configured to inhibit onset of a symptom of the chronic condition; and

deliver abortive electrical stimulation to the cranial nerve at a second stimulation intensity within a second range of stimulation intensity thresholds determined based on patient perception while a symptom of the chronic condition is occurring, wherein the abortive stimulation is configured to reduce an effect of a symptom of the chronic condition.