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Transthyretin antibodies and uses thereof

  • US 9,790,269 B2
  • Filed: 02/07/2014
  • Issued: 10/17/2017
  • Est. Priority Date: 02/08/2013
  • Status: Active Grant
First Claim
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1. An anti-transthyretin (TTR) monoclonal antibody that exhibits selective binding to non-native TTR under physiologically relevant conditions as compared to tetrameric TTR for said antibody binding, wherein the monoclonal antibody binds to an epitope consisting essentially of amino acid residues 49-61 or 109-121 in SEQ ID. No. 1 with a Kd equal to or less than 1 nM, wherein the epitope has a length of 10, 11, 12, 13, 14, 15, or 16 amino acids.

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