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Optogenetic probes for measuring membrane potential

  • US 9,791,455 B2
  • Filed: 06/15/2015
  • Issued: 10/17/2017
  • Est. Priority Date: 08/23/2010
  • Status: Active Grant
First Claim
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1. An isolated and purified nucleic acid encoding Archaerhodopsin 3 with a mutation of D95 to reduce ion pumping activity compared to Arch 3 WT, the isolated and purified nucleic acid being operably linked to a nucleic acid encoding at least one additional fluorescent protein capable of indicating ion concentration in a cell.

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