Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images

• US 9,795,301 B2
• Filed: 05/25/2011
• Issued: 10/24/2017
• Est. Priority Date: 05/25/2010
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Fleming, Christine, Bouma, Brett Eugene, Gardecki, Joseph, Tearney, Guillermo J.
• Primary Examiner(s): Lyons, Michael A
• Application Number:
  US13/115,332
• Publication Number:
  US 20110292400A1
• Time in Patent Office: 2,344 Days
• Field of Search: 356456
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01N 2021/1787 Tomographic, i.e. computerised reconstruction from projective measurements
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 2201/129 Using chemometrical methods
• CPC Class Codes: G01N 2201/1293 resolving multicomponent spectra

Abstract

According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information.

Claims

1. An apparatus for generating information for at least one structure, comprising:

at least one interferometer first arrangement which is configured to receive at least one single-spatial mode first radiation from the at least one structure and at least one second radiation from a reference, and combine only one of the first radiation with the at least one second radiation to generate a single third radiation;

at least one computer second arrangement which is configured to (i) generate spectroscopic data as a function of the single third radiation; and

(ii) reduce at least one scattering effect in the spectroscopic data using only the single third radiation to generate the information.

2. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to reduce an intensity variation of the of the spectroscopic data.

3. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to smooth the spectroscopic data based a polynomial fit to the spectroscopic data.

4. The apparatus according to claim 3, wherein the at least one structure is an anatomical structure.

5. The apparatus according to claim 4, wherein the anatomical structure is an artery wall.

6. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to classify a type of the structure based on the spectroscopic data.

7. A method for generating information for at least one structure, comprising:

receiving at least one single-spatial mode first radiation from the at least one structure and at least one second radiation from a reference;

causing an interference of only one of the first radiation with the at least one second radiation to generate a single third radiation;

generating spectroscopic data as a function of the single third radiation; and

with a computing arrangement, causing a reduction at least one scattering effect in the spectroscopic data using only the single third radiation to generate the information.

8. An apparatus for generating information for at least one structure, comprising:

at least one interferometer first arrangement which is configured to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation; and

at least one computer second arrangement which is configured to (i) generate spectroscopic data as a function of only the at least one third radiation, and (ii) classify a type of the structure based on the spectroscopic data using a statistical pattern recognition procedure to generate the information.

9. The apparatus according to claim 8, wherein the classification includes a generation of a probability that the structure is of a particular type.

10. The apparatus according to claim 9, wherein the probability is provided for a depth-resolved two-dimensional map.

11. The arrangement according to claim 8, wherein the at least one structure is an anatomical structure.

12. The apparatus according to claim 11, wherein the anatomical structure is an artery wall.

13. The apparatus according to claim 8, wherein the type is a type of tissue or a type of plaque.

14. The apparatus according to claim 8, wherein the plaque is an atherosclerotic plaque.

15. The apparatus of claim 8, wherein the statistical pattern recognition procedure provides more than two possible outcomes.

16. A method for generating information for at least one structure, comprising:

receiving at least one first radiation from the at least one structure and at least one second radiation from a reference;

causing an interference of the first and second radiations to generate a single third radiation;

generating spectroscopic data as a function of only the single third radiation; and

with a computer arrangement, classifying a type of the structure based on the spectroscopic data using a statistical pattern recognition procedure using the third radiation to generate the information.

17. An apparatus for generating information for at least one first structure and at least one second structure, comprising:

at least one interferometer first arrangement which is configured to receive at least one first radiation from the at least one first structure, at least one second radiation from the at least one second structure and at least one third radiation from a reference, and interfere the first, second and third radiations to generate a single fourth radiation; and

at least one computer second arrangement which is configured to (i) determine first data regarding the at least one first structure and the second data regarding the at least one second structure, (ii) generate statistical pattern recognition data from spectra as a function of the first and second data using the fourth radiation, and (iii) compare the statistical pattern recognition data with the predetermined data to determine the information.

18. The apparatus according to claim 17, wherein the at least one structure is an anatomical structure.

19. The apparatus according to claim 18, wherein the anatomical structure is an artery wall.

20. The apparatus according to claim 17, wherein the type is a type of tissue or a type of plaque.

21. A method for generating information for at least one first structure and at least one second structure, comprising:

receiving at least one first radiation from the at least one first structure, at least one second radiation from the at least one second structure and at least one third radiation from a reference;

causing an interference of the first, second and third radiations to generate a single fourth radiation;

determining first data regarding the at least one first structure and the second data regarding the at least one second structure;

generating statistical pattern recognition data from spectra using the fourth radiation as a function of the first and second data; and

with a computer arrangement, comparing the statistical pattern recognition data with predetermined data to determine the information.

22. An apparatus for generating information for at least one structure, comprising:

at least one interferometer first arrangement which is configured to receive at least one single-spatial mode first radiation from the at least one structure and at least one second radiation from a reference, and combine only one of the first radiation with the at least one second radiations to generate a single third radiation; and

at least one computer second arrangement which is configured to generate spectroscopic data as a function of the single third radiation, wherein the spectroscopic data represents, at least partially, an interference between the first and second radiations, and wherein the at least one second arrangement is further configured to reduce at least one scattering effect in the spectroscopic data to generate the information based only on the single third radiation.