Tissue marker for multimodality radiographic imaging
First Claim
Patent Images
1. A radiographic marker, comprising:
- a container wall enclosing an internal chamber and including a permeable portion; and
a sensing medium received within the internal chamber, the sensing medium initially including at least one of a first liquid, a gas portion and a solid portion, the sensing medium configured to be detectable using a first imaging modality;
wherein the permeable portion is semi-permeable to permit, when injected or surgically implanted into a patient'"'"'s body, transfer of enough of a second liquid through the permeable portion of the chamber wall into the inner chamber while confining the sensing medium within the inner chamber to change a ratio of gas to liquid of the sensing medium within the internal chamber to produce a detectable change in signal intensity using a second imaging modality that is of a different type than the first imaging modality.
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Abstract
A radiographic marker containing a sensing medium that initially includes a gas and liquid mixture for producing increased signal intensity in a first imaging modality. The radiographic marker can have a permeable portion allowing the exchange of the gases or liquids of the sensing medium to be changed or exchanged for at least a second fluid in the surrounding tissue to reduce the bubbles or air pockets created by the gas portion of the sensing medium. The change or exchange of gas for the second liquid in the radiographic marker produces a detectable signal intensity of the radiographic marker in a second imaging modality different from the first imaging modality.
121 Citations
34 Claims
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1. A radiographic marker, comprising:
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a container wall enclosing an internal chamber and including a permeable portion; and a sensing medium received within the internal chamber, the sensing medium initially including at least one of a first liquid, a gas portion and a solid portion, the sensing medium configured to be detectable using a first imaging modality; wherein the permeable portion is semi-permeable to permit, when injected or surgically implanted into a patient'"'"'s body, transfer of enough of a second liquid through the permeable portion of the chamber wall into the inner chamber while confining the sensing medium within the inner chamber to change a ratio of gas to liquid of the sensing medium within the internal chamber to produce a detectable change in signal intensity using a second imaging modality that is of a different type than the first imaging modality. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of making a radiographic marker, comprising:
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providing a chamber wall defining an internal chamber, the chamber wall including a permeable portion; at least partially filling the internal chamber with a sensing medium initially including at least one of a first liquid, gas portion and a solid portion, the sensing medium configured to be detectable using a first imaging modality; and sealing the chamber wall to enclose the internal chamber;
wherein the permeable portion is semi-permeable to permit, when injected or surgically implanted into a patient'"'"'s body, transfer of enough of a second liquid through the permeable portion of the chamber wall into the inner chamber while confining the sensing medium within the inner chamber to change a ratio of gas to liquid of the sensing medium within the internal chamber to produce a detectable change in signal intensity using a second imaging modality that is of a different type than the first imaging modality. - View Dependent Claims (29, 30, 31, 32, 33, 34)
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Specification