Oil-based foamable carriers and formulations
First Claim
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1. A foamable pharmaceutical composition, comprising a foamable carrier and a propellant in a container, wherein the foamable carrier comprises:
- a. about 60% to about 98% by weight of the foamable carrier of a liquid oil comprising a mixture of a mineral oil and one or more liquid oils selected from the group consisting of a medium chain triglyceride oil, a vegetable oil, an essential oil and a silicone oil;
b. about 2% to about 40% by weight of the foamable carrier of a surfactant, wherein the surfactant comprises at least one glyceride; and
c. a wax selected from the group consisting of beeswax, hydrogenated castor oil, candelilla wax, and a mixture of any two or more thereof;
wherein the composition comprises less than 1.5% water,wherein the foamable carrier is capable of producing a foam having a specific gravity in the range of 0.05 to 0.20,wherein the foamable carrier is selected to produce a foam having a collapse time in excess of about 180 seconds, and wherein the composition does not include a polymer stabilizer.
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Abstract
A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
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Citations
37 Claims
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1. A foamable pharmaceutical composition, comprising a foamable carrier and a propellant in a container, wherein the foamable carrier comprises:
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a. about 60% to about 98% by weight of the foamable carrier of a liquid oil comprising a mixture of a mineral oil and one or more liquid oils selected from the group consisting of a medium chain triglyceride oil, a vegetable oil, an essential oil and a silicone oil; b. about 2% to about 40% by weight of the foamable carrier of a surfactant, wherein the surfactant comprises at least one glyceride; and c. a wax selected from the group consisting of beeswax, hydrogenated castor oil, candelilla wax, and a mixture of any two or more thereof; wherein the composition comprises less than 1.5% water, wherein the foamable carrier is capable of producing a foam having a specific gravity in the range of 0.05 to 0.20, wherein the foamable carrier is selected to produce a foam having a collapse time in excess of about 180 seconds, and wherein the composition does not include a polymer stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 27, 30, 33, 34, 35, 36, 37)
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18. A foamable pharmaceutical composition, comprising a foamable carrier and a propellant in a container, wherein the foamable carrier comprises:
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a. about 60% to about 98% by weight of the foamable carrier of a liquid oil comprising a mixture of a mineral oil and one or more liquid oils selected from the group consisting of a medium chain triglyceride oil, a vegetable oil, an essential oil and a silicone oil; b. about 0.2% to about 8% by weight of the foamable carrier of a surfactant wherein the surfactant comprises at least one glyceride; and c. a wax selected from the group consisting of beeswax, hydrogenated castor oil, candelilla wax, and a mixture of any two or more thereof; and wherein the composition comprises less than 1.5% water, wherein the foamable carrier is capable of producing a foam having a specific gravity in the range from 0.05 to 0.20, wherein the foamable carrier is selected to produce a foam having a collapse time in excess of about 180 seconds, and wherein the composition does not include a polymer stabilizer. - View Dependent Claims (24, 25, 26, 28, 31)
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23. A foamable pharmaceutical composition, comprising a foamable carrier and a propellant in a container, the foamable carrier comprising:
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a. about 60% to about 98% by weight of the foamable carrier of a liquid oil comprising a mixture of a mineral oil and one or more liquid oils selected from the group consisting of a medium chain triglyceride oil, a vegetable oil, an essential oil and a silicone oil; b. about 2% to about 40% by weight of the foamable carrier of a surfactant wherein the surfactant comprises at least one glyceride; c. a wax selected from the group consisting of beeswax, hydrogenated castor oil, candelilla wax, and a mixture of any two or more thereof; d. a foam adjuvant selected from the group consisting of a fatty alcohol, a fatty acid a hydroxyl fatty acid and a mixture thereof; and e. an active agent comprising a tetracycline antibiotic selected from the group consisting of a minocycline, a doxycycline and a mixture of any two or more thereof; and wherein the composition comprises less than 1.5% water, wherein the foamable carrier is capable of producing a foam having a specific gravity in the range from 0.05 to 0.20, wherein the foamable carrier is selected to produce a foam having a collapse time in excess of about 180 seconds, and wherein the composition does not include a polymer stabilizer. - View Dependent Claims (29, 32)
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Specification