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Microneedles with improved open channel cross-sectional geometries

  • US 9,795,775 B2
  • Filed: 05/20/2014
  • Issued: 10/24/2017
  • Est. Priority Date: 05/23/2013
  • Status: Active Grant
First Claim
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1. A drug delivery device, comprising:

  • a reservoir containing a liquid drug formulation; and

    a microneedle assembly in fluid communication with the reservoir, the microneedle assembly including a support defining an upper surface and a lower surface, the microneedle assembly further including a plurality of microneedles extending from the lower surface, each microneedle defining an open channel for receiving the drug formulation, the open channel having a normalized hydraulic radius ranging from 0.1 to 0.8, the open channel further having a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein,wherein the drug formulation and a cross-sectional geometry of the open channel is selected and configured based on an interaction between the drug formulation and the open channel such that the liquid-to-solid interfacial energy exceeds the liquid-to-vapor interfacial energy as a fluid length of the fixed volume of drug formulation is increased within the open channel.

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