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Polypeptide and immune modulation

  • US 9,796,762 B2
  • Filed: 04/10/2014
  • Issued: 10/24/2017
  • Est. Priority Date: 04/10/2013
  • Status: Active Grant
First Claim
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1. A method of treating a gastrointestinal inflammatory disorder or an autoimmune disorder, comprising administering to a subject in need thereof a Roseburia flagellin,wherein said Roseburia flagellin is a FlaA1 polypeptide with a sequence that has at least 95% identity to SEQ ID NO:

  • 2 or a fragment thereof, andwherein said Roseburia flagellin comprises amino acids 79-117 of SEQ ID NO;

    2 and binds to TLR5.

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