Polypeptide and immune modulation
First Claim
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1. A method of treating a gastrointestinal inflammatory disorder or an autoimmune disorder, comprising administering to a subject in need thereof a Roseburia flagellin,wherein said Roseburia flagellin is a FlaA1 polypeptide with a sequence that has at least 95% identity to SEQ ID NO:
- 2 or a fragment thereof, andwherein said Roseburia flagellin comprises amino acids 79-117 of SEQ ID NO;
2 and binds to TLR5.
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Abstract
The present invention relates to Roseburia flagellin, and/or a polynucleotide sequence encoding said Roseburia flagellin, and/or a vector comprising said polynucleotide sequence, and/or a host cell, including bacteria, comprising said vector, and/or a host cell, including bacteria, comprising said polynucleotide sequence, for use in modulating the inflammation of a tissue or an organ in a subject.
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Citations
22 Claims
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1. A method of treating a gastrointestinal inflammatory disorder or an autoimmune disorder, comprising administering to a subject in need thereof a Roseburia flagellin,
wherein said Roseburia flagellin is a FlaA1 polypeptide with a sequence that has at least 95% identity to SEQ ID NO: - 2 or a fragment thereof, and
wherein said Roseburia flagellin comprises amino acids 79-117 of SEQ ID NO;
2 and binds to TLR5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- 2 or a fragment thereof, and
Specification