Techniques to improve polyurethane membranes for implantable glucose sensors
First Claim
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1. An implantable device for measuring an analyte in a biological fluid, comprising:
- an implantable sensor comprising an electrochemically reactive surface; and
a membrane disposed over at least a portion of the electrochemically reactive surface, wherein the membrane comprises a matrix comprising a first polymer and a second polymer dispersed throughout the matrix, wherein the first polymer is polyurethane urea, wherein the second polymer comprises at least one hydrophilic component, wherein the hydrophilic component of the second polymer forms in the membrane hydrophilic segments along which the analyte diffuses.
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Abstract
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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Citations
10 Claims
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1. An implantable device for measuring an analyte in a biological fluid, comprising:
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an implantable sensor comprising an electrochemically reactive surface; and a membrane disposed over at least a portion of the electrochemically reactive surface, wherein the membrane comprises a matrix comprising a first polymer and a second polymer dispersed throughout the matrix, wherein the first polymer is polyurethane urea, wherein the second polymer comprises at least one hydrophilic component, wherein the hydrophilic component of the second polymer forms in the membrane hydrophilic segments along which the analyte diffuses. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification