Nucleotide analogs

• US 9,801,884 B2
• Filed: 06/02/2016
• Issued: 10/31/2017
• Est. Priority Date: 09/15/2014
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Hostetler, Karl Y., Beadle, James R., Valiaeva, Nadejda
• Primary Examiner(s): Cruz, Kathrien
• Assistant Examiner(s): Coppins, Janet L
• Application Number:
  US15/171,935
• Publication Number:
  US 20170037068A1
• Time in Patent Office: 516 Days
• Field of Search: 514 81, 544244
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/20 for DNA viruses
• CPC Class Codes: C07F 9/65616 containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
• CPC Class Codes: C07F 9/657181 the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
• CPC Class Codes: C07F 9/65742 non-condensed with carbocyclic rings or heterocyclic rings or ring systems
• CPC Class Codes: C07F 9/65744 condensed with carbocyclic or heterocyclic rings or ring systems
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Disclosed herein, inter alia, are acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for treating and/or ameliorating a papillomavirus infection.

Claims

1. A compound selected from the group consisting of:

2. The compound of claim 1 with structure:

3. The compound of claim 1 with structure:

4. The compound of claim 1 with structure:

5. The compound of claim 1 with structure:

6. The compound of claim 1 with structure:

7. The compound of claim 1 with structure:

8. The compound of claim 1 with structure:

9. The compound of claim 1 with structure:

10. The compound of claim 1 with structure:

11. The compound of claim 1 with structure: