Oxygen-enabled fluid

• US 9,801,906 B2
• Filed: 11/08/2016
• Issued: 10/31/2017
• Est. Priority Date: 03/30/2016
• Status: Active Grant

• Current Assignee: Baylor University
• Original Assignee: Baylor University
• Inventors: Bruce, Erica D., Sayes, Christie, Woodmansee, Jr., John W.
• Primary Examiner(s): Arnold, Ernst V
• Assistant Examiner(s): Chang, Kyung Sook
• Application Number:
  US15/346,549
• Publication Number:
  US 20170281675A1
• Time in Patent Office: 357 Days
• Field of Search: None
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/6823 Double chain ricin
• CPC Class Codes: A61K 47/6921 the form being a particulate, a powder, an adsorbate, a bead or a sphere
• CPC Class Codes: A61K 47/6923 the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04

Abstract

A colloid or crystalline solution with the addition of poly-oxygenated metal hydroxide particles. The solution is configured to treat a condition of a mammal, including a human individual and an animal including a depletion of hemoglobin and hemorrhagic shock. The solution can be intravenously administered. In some embodiments, the poly-oxygenated metal hydroxide is an aluminum poly-oxygenated hydroxide, such as Ox66™. The poly-oxygenated metal hydroxide may have particles having a diameter of less than or equal to 1 um, and specifically having a diameter of less than or equal to 100 nm.

Claims

1. An oxygen enabled solution, comprising:

a fluid comprising a colloid or crystalline solution; and

a poly-oxygenated metal hydroxide material solubilized in the fluid, wherein the poly-oxygenated metal hydroxide material comprises a clathrate compound having free O₂ gas molecules.

2. The oxygen enabled solution as specified in claim 1 wherein the poly-oxygenated metal hydroxide material is dissolved in the fluid and also retains its integrity.

3. The oxygen enabled solution as specified in claim 1 wherein the solution is a 75-90% colloid or crystalline solution with 10-25% addition of the poly-oxygenated metal hydroxide material.

4. The oxygen enabled solution as specified in claim 3 wherein the solution is a 75-90% colloid with 10-25% addition of the poly-oxygenated metal hydroxide material.

5. The oxygen enabled solution as specified in claim 3 wherein the fluid is phosphate buffered saline (PBS).

6. The oxygen enabled solution as specified in claim 5 wherein the fluid is a lactated Ringers solution (LRS).

7. The oxygen enabled solution as specified in claim 3 wherein the solution is a 75-90% crystalline solution with 10-25% addition of the poly-oxygenated metal hydroxide material.

8. The oxygen enabled solution as specified in claim 1 wherein the fluid is phosphate buffered saline (PBS).

9. The oxygen enabled solution as specified in claim 3 wherein the solution has a concentration range of poly-oxygenated metal hydroxide from 0.1 mg/l to 1000 mg/l.

10. The oxygen enabled solution as specified in claim 1 wherein the poly-oxygenated metal hydroxide material comprises particles that are surface modified.

11. The oxygen enabled solution as specified in claim 10 wherein the poly-oxygenated metal hydroxide material comprises nano-sized particles surface modified with polyethylene glycol (PEG).

12. The oxygen enabled solution as specified in claim 1 wherein the poly-oxygenated metal hydroxide material comprises a poly-oxygenated aluminum hydroxide.

13. The oxygen enabled solution as specified in claim 1 wherein the poly-oxygenated metal hydroxide material comprises particles having a diameter of less than or equal to 100 nm.

14. The oxygen enabled solution as specified in claim 1 wherein the poly-oxygenated metal hydroxide material comprises particles having a diameter of less than or equal to 10 um.

15. An oxygen enabled solution, comprising:

a fluid comprising a colloid or crystalline solution; and

a poly-oxygenated metal hydroxide material disposed in the fluid, wherein the poly-oxygenated metal hydroxide material comprises a clathrate compound having free O₂ gas molecules, wherein the solution has a concentration range of poly-oxygenated metal hydroxide from 0.1 mg/l to 1000 mg/l.