Magnetic nanostructures as theranostic agents

• US 9,801,952 B2
• Filed: 08/04/2015
• Issued: 10/31/2017
• Est. Priority Date: 10/30/2009
• Status: Active Grant

• Current Assignee: Northwestern University
• Original Assignee: Northwestern University
• Inventors: Dravid, Vinayak P.
• Primary Examiner(s): Justice, Gina
• Application Number:
  US14/817,710
• Publication Number:
  US 20150335743A1
• Time in Patent Office: 819 Days
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 47/6865 the tumour determinant being from skin, nerves or brain cancer cell
• CPC Class Codes: A61K 47/6923 the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
• CPC Class Codes: A61K 49/1833 having a (super)(para)magnetic core coated or functionalised with a small organic molecule oligomeric, polymeric, dendrimeric A61K49/1851
• CPC Class Codes: A61K 49/186 the organic macromolecular compound being polyethyleneglycol [PEG]
• CPC Class Codes: A61K 49/1875 coated or functionalised with an antibody
• CPC Class Codes: A61N 2/004 specially adapted for a specific therapy
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer'"'"'s disease and related diseases and conditions.

Claims

1. A method, comprising

a) administering a magnetic nanostructure comprising i) a magnetic nanostructure coated with a non-magnetic coating;

and ii) a targeting agent, wherein said targeting agent targets said nanostructure to a Medulloblastoma cell of a subject;

b) detecting the presence of said cancer cell in said subject by identifying said magnetic nanostructure; and

c) destroying said cancer cell by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.

2. The method of claim 1, wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.

3. The method of claim 1, wherein said targeting agent is an antibody.

4. The method of claim 1, wherein said magnetic nanostructure is present in a stable suspension.

5. A method, comprising

a) administering a magnetic nanostructure comprising i) a magnetic nanostructure coated with a non-magnetic coating;

and ii) a targeting agent, wherein said targeting agent targets said nanostructure to a Medulloblastoma cell to a subject; and

b) detecting the presence of said cancer cell in said subject by identifying said magnetic nanostructure.

6. The method of claim 5, further comprising the step of destroying said cancer cell by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.

7. The method of claim 5, wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.

8. The method of claim 5, wherein said targeting agent is an antibody.

9. The method of claim 5, wherein said magnetic nanostructure is present in a stable suspension.