Flowable matrix compositions and methods
First Claim
1. A soft tissue matrix composition for use in a patient treatment, the composition consisting of a cryofractured human soft tissue material having a mechanically disrupted extracellular matrix collagen or macrostructure and a partially disrupted collagen microfibrillar architecture, wherein the cryofractured tissue material is in a naturally hydrated state, the hydration comprising the natural interstitial water of the cryofractured soft tissue material that is present prior to cryofractionation.
1 Assignment
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Accused Products
Abstract
Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.
239 Citations
67 Claims
- 1. A soft tissue matrix composition for use in a patient treatment, the composition consisting of a cryofractured human soft tissue material having a mechanically disrupted extracellular matrix collagen or macrostructure and a partially disrupted collagen microfibrillar architecture, wherein the cryofractured tissue material is in a naturally hydrated state, the hydration comprising the natural interstitial water of the cryofractured soft tissue material that is present prior to cryofractionation.
- 22. A soft tissue matrix composition for use in a patient treatment, the composition consisting of a cryofractured and triturated human soft tissue material having a mechanically disrupted extracellular matrix collagen or macrostructure and a partially disrupted collagen microfibrillar architecture, wherein the cryofractured and triturated tissue material is in a naturally hydrated state, the hydration comprising the natural interstitial water of the cryofractured and triturated human soft tissue material that is present prior to cryofractionation and trituration.
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43. A soft tissue matrix composition for use in a patient treatment prepared by a method consisting of:
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providing a human soft tissue material; processing the human soft tissue material to mechanically disrupt the extracellular matrix collagen or macrostructure and a partially disrupt the collagen microfibrillar architecture by a process selected from the group consisting of; (i) cryofracturing the human soft tissue material; (ii) cryofracturing and washing the human soft tissue material; (iii) cryofracturing and triturating the human soft tissue material; and (iv) cryofracturing, triturating, and washing the human soft tissue material, wherein the processed tissue material is in a naturally hydrated state, the hydration comprising a substantial amount of the natural interstitial water of the human soft tissue material. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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Specification