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Apparatus for electrically mediated delivery of therapeutic agents

  • US 9,802,035 B2
  • Filed: 05/12/2016
  • Issued: 10/31/2017
  • Est. Priority Date: 03/08/2004
  • Status: Active Grant
First Claim
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1. A method comprising:

  • administering a therapeutic agent to a predetermined site within the tissue of a patient by;

    loading the therapeutic agent into an apparatus comprising;

    a) a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to a total cross sectional area of all electrodes;

    b) an applicator housing an inanimate source of energy operatively connected to said plurality of electrodes, and wherein said source of energy is configured to provide a force sufficient to rapidly insert the electrodes; and

    c) an electrical field generator operatively connected to said electrodes at least in their deployed state; and

    d) at least one cantilevered extension of a cartridge that engages an injection drive mechanism of said applicator to passively prime said inanimate source of energy when said cartridge is inserted into said applicator;

    positioning the apparatus against the patient;

    deploying the electrodes using the source of energy;

    generating an electric field between the electrodes at the predetermined site; and

    delivering the therapeutic agent to the predetermined site;

    wherein the administering does not result in tenting of the skin of the patient or significant distortion of the electrodes.

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