Variable output ramping for an implantable medical device

• US 9,802,048 B2
• Filed: 02/27/2014
• Issued: 10/31/2017
• Est. Priority Date: 10/28/2005
• Status: Active Grant

• Current Assignee: LivaNova USA, Inc. (LivaNova Plc)
• Original Assignee: Cyberonics, Inc
• Inventors: Armstrong, Randolph K.
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US14/191,864
• Publication Number:
  US 20140180364A1
• Time in Patent Office: 1,342 Days
• Field of Search: 607 2, 607 62, 607 73, 607116
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

A method, system, and apparatus for providing a stimulation signal comprising a variable ramping portion using an implantable medical device (IMD). The first electrical comprises a first ramping portion. The first ramping portion comprises a first parameter and having a first value. The first electrical signal is applied to a target location of the patient'"'"'s body. A second electrical signal comprising a second ramping portion is generated. The second ramping portion comprises the first parameter having a second value that is different from the first value. The second electrical signal is applied to a target location of the patient'"'"'s body.

Claims

1. A method for providing an electrical neurostimulation therapy to a patient using an implantable medical device, comprising:

determining a first rate of change of an amplitude of a first ramping portion of an electrical signal, wherein the first ramping portion is a portion where the amplitude is changed prior to delivery of a therapeutic level of stimulation;

delivering the electrical signal comprising the first ramping portion with the first rate of change of the amplitude and the therapeutic level of stimulation to a target location of a patient'"'"'s body;

analyzing efficacy data of the therapy applied using the electrical signal;

modifying the electrical signal by modifying the first rate of change of the amplitude of the first ramping portion using the efficacy data to create a modified electrical signal with the therapeutic level of stimulation and a modified ramping portion comprising a second rate of change of the amplitude;

delivering the modified electrical signal with the modified ramping portion and the therapeutic level of stimulation to the target location of the patient'"'"'s body.

2. The method of claim 1, wherein determining the first rate of change of the amplitude comprises programming the first rate of change of the amplitude.

3. The method of claim 1, wherein modifying the electrical signal by modifying the first rate of change of the amplitude of the first ramping portion comprises re-programming the first rate of change of the amplitude to provide the second rate of change of the amplitude.

4. The method of claim 1, wherein modifying the electrical signal by modifying the first rate of change of the amplitude of the first ramping portion comprises performing a random modification of the first rate of change of the amplitude.

5. The method of claim 1, wherein modifying the electrical signal by modifying the first rate of change of the amplitude of the first ramping portion comprises providing a multi-phasic signal for the first ramping portion.

6. The method of claim 1, wherein modifying the electrical signal by modifying the first rate of change of the amplitude of the first ramping portion comprises modifying the amplitude from at least one of a zero level to a non-zero level or a non-zero level to a zero level.

7. The method of claim 1, wherein analyzing efficacy data of the therapy applied using the electrical signal comprises comparing the efficacy data to prior efficacy data, and wherein modifying the electrical signal by modifying the first rate of change of the amplitude of the first ramping portion comprises modifying the ramping portion in response to determining that the efficacy data is lower than the prior efficacy data.

8. A method for providing an electrical neurostimulation therapy to a patient using an implantable medical device, comprising:

determining a characteristic of a ramping portion of a stimulation signal comprising the ramping portion and a therapeutic level of stimulation, wherein the characteristic of the ramping portion is provided by the implantable medical device using efficacy data of a treatment applied using the stimulation signal, the characteristic selected from a group including a rate of change of a pulse width, and a rate of change of a frequency, wherein the first ramping portion is a portion where the characteristic of the ramping portion is varied prior to delivery of the therapeutic level of stimulation; and

providing the stimulation signal based upon the characteristic of the ramping portion.

9. The method of claim 8, wherein determining the characteristic of the ramping portion comprises programming the characteristic of the ramping portion of the stimulation signal.

10. An implantable medical device for providing an electrical neurostimulation therapy to a patient, comprising:

a stimulation unit to provide a first electrical signal comprising a first ramping portion and a therapeutic level of stimulation, the first ramping portion comprising a first characteristic selected from a group including a rate of change of a pulse width or a rate of change of a frequency, wherein the first ramping portion is a portion where the first characteristic is changed prior to delivery of the therapeutic level of stimulation; and

a controller operatively coupled to the stimulation unit, wherein the controller determines the first characteristic using efficacy data of a treatment applied using the first electrical signal and controls a first value of the first characteristic of the first ramping portion.

11. The implantable medical device of claim 10, wherein the controller performs an operation to change the first value of the first characteristic randomly to generate a second value for the first characteristic to enable the stimulation unit to provide a second ramping portion for a second electrical signal.

12. The implantable medical device of claim 10, wherein the controller controls a second value for the first characteristic to provide a second ramping portion for a second electrical signal, the implantable medical device further comprising a ramping signal generator to generate the first ramping portion of the first electrical signal and the second ramping portion of the second electrical signal.

13. The implantable medical device of claim 12, wherein the controller is a multi-phasic controller to provide a multi-phasic signal for at least one of the first ramping portion and the second ramping portion.

14. The implantable medical device of claim 13, wherein the multi-phasic controller comprises a multi-phasic pulse description array comprising data for providing at least one feature for at least one pulse of the first electrical signal and the second electrical signal during a first phase and for providing at least one feature for the at least one pulse during a second phase.

15. The implantable medical device of claim 12, further comprising a sensor for a physiological parameter to provide physiological data to the controller, the controller configured to control at least one of the first value and the second value of the first characteristic of at least one of the first electrical signal and the second electrical signal using the physiological data.

16. The implantable medical device of claim 10, wherein the first ramping portion of the first electrical signal further comprises a second characteristic selected from the group consisting of an amplitude, a rate of change of the amplitude, a time period of the rate of change of the amplitude, the pulse width, the rate of change of the pulse width, a time period of the rate of change of the pulse width, the frequency, the rate of change of the frequency, a time period of the rate of change of the frequency, and a duration of a time period of the first ramping portion.