Polymer particles
First Claim
Patent Images
1. A polymer particle comprising:
- at least one monomer including at least one functional group; and
at least one crosslinker;
wherein the polymer particle has a spherical diameter between about 40 μ
m and about 1,200 μ
m and is susceptible to degradation through hydrolysis or enzymatic action, and wherein the degradation provides less than about 10% of the polymer particle intact after about 5 days.
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Accused Products
Abstract
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
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Citations
20 Claims
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1. A polymer particle comprising:
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at least one monomer including at least one functional group; and at least one crosslinker; wherein the polymer particle has a spherical diameter between about 40 μ
m and about 1,200 μ
m and is susceptible to degradation through hydrolysis or enzymatic action, and wherein the degradation provides less than about 10% of the polymer particle intact after about 5 days.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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9. The polymer particle of claim 7, wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.
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10. The polymer particle of claim 9, including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.
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11. The polymer particle of claim 1, wherein the at least one monomer is dimethylacrylamide and the at least one crosslinker is bis-glycidyl amino alcohol.
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12. The polymer particle of claim 1, wherein the at least one monomer is acrylamide and the at least one crosslinker is bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
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13. A method of making a polymer particle comprising:
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reacting a prepolymer solution including at least one monomer including at least one functional group, at least one crosslinker susceptible to degradation through hydrolysis or enzymatic action, and an initiator in an oil; and forming the polymer particle, wherein the polymer particle has a spherical diameter between about 40 μ
m and about 1,200 μ
m, and wherein the degradation provides less than about 10% of the polymer particle intact after about 5 days. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification