Slip-induced compartmentalization
First Claim
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1. A system for compartmentalization comprising a device, a target fluid, an immiscible fluid, and a surface energy,wherein the device comprises(i) a first layer comprising a first region;
- and(ii) a second layer comprising a plurality of second regions;
wherein said first region and said plurality of second regions are connected by relative movement of the first and second layers from a first position, wherein the first region is not connected to the plurality of second regions, to a second position, wherein the first region is connected to the plurality of second regions to form a plurality of combined regions,wherein, in said first position, said target fluid is present in said first region, and wherein relative movement of said device from said first position to said second position results in separation of said target fluid into compartments that are separated by said immiscible fluid and located in said plurality of combined regions, andwherein, in said second position, the surface energy of the system is reduced from a first surface energy before said separation of said target fluid into said compartments to a second surface energy after said separation of said target fluid into said compartments.
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Abstract
The present invention relates to fluidic devices for compartmentalizing samples. In particular, the devices and related systems and methods allow for compartmentalization by using one or more first chambers connect by a first channel (e.g., where the cross-sectional dimension of the first channel is less than the cross-sectional dimension of at least one first chamber).
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Citations
32 Claims
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1. A system for compartmentalization comprising a device, a target fluid, an immiscible fluid, and a surface energy,
wherein the device comprises (i) a first layer comprising a first region; - and
(ii) a second layer comprising a plurality of second regions; wherein said first region and said plurality of second regions are connected by relative movement of the first and second layers from a first position, wherein the first region is not connected to the plurality of second regions, to a second position, wherein the first region is connected to the plurality of second regions to form a plurality of combined regions, wherein, in said first position, said target fluid is present in said first region, and wherein relative movement of said device from said first position to said second position results in separation of said target fluid into compartments that are separated by said immiscible fluid and located in said plurality of combined regions, and wherein, in said second position, the surface energy of the system is reduced from a first surface energy before said separation of said target fluid into said compartments to a second surface energy after said separation of said target fluid into said compartments. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification