Biological information measurement device, and biological information measurement method using same

• US 9,804,115 B2
• Filed: 03/10/2017
• Issued: 10/31/2017
• Est. Priority Date: 04/19/2012
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Holdings Co., Ltd.
• Inventors: Shinno, Teppei, Hironaka, Shouko
• Primary Examiner(s): GRAY, FRANCIS C
• Application Number:
  US15/456,093
• Publication Number:
  US 20170234824A1
• Time in Patent Office: 235 Days
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/48707 by electrical means G01N33/49, G01N33/493 take precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

The present invention has an object of improving the measurement accuracy in a biological information measurement device, e.g., for measuring a blood glucose level. The device is configured to be able to change at least one of i) a voltage value to be applied to the second input terminal and the third input terminal (i.e., the blood component measurement counter electrode 7 and the blood component measurement working electrode 6) in the second biological information measurement mode D and ii) a voltage application time during which a voltage is applied to the second input terminal and the third input terminal in the second biological information measurement mode D based on the first biological information in the first biological information measurement mode A. A hematocrit value is measured in the first biological information measurement mode A, and a glucose value is measured based on the hematocrit value in the second biological information measurement mode D.

Claims

1. A biological information measurement device to which a biosensor is to be attached, the biosensor comprising a first electrode, a second electrode, a third electrode, and a reagent portion provided between the second electrode and the third electrode,

the biological information measurement device comprising:

a first input terminal to be connected to the first electrode;

a second input terminal to be connected to the second electrode;

a third input terminal to be connected to the third electrode;

a voltage application portion that applies a voltage to the first input terminal, the second input terminal, and the third input terminal; and

a control portion that is connected to the voltage application portion,

wherein the control portion is configured to perform a first biological information measurement mode, then a voltage application stop mode, and then a second biological information measurement mode,

in the first biological information measurement mode, first biological information is measured based on a current flowing through the first input terminal,

in the voltage application stop mode, the application of the voltage to the first, second and third input terminals are stopped, and

in the second biological information measurement mode, second biological information is measured by applying a voltage to the second input terminal and the third input terminal,

the first biological information is a hematocrit value,

when the hematocrit value represents a first hematocrit value, the control portion applies a first voltage to the second input terminal and the third input terminal in the second biological information measurement mode, or applies a voltage to the second input terminal and the third input terminal for a first application time in the second biological information measurement mode, and stops the application of the voltage in the voltage application stop mode for a first stop time,

when the hematocrit value represents a second hematocrit value, the control portion applies a second voltage to the second input terminal and the third input terminal in the second biological information measurement mode, or applies a voltage to the second input terminal and the third input terminal for a second application time in the second biological information measurement mode, and stops the application of the voltage in the voltage application stop mode for a second stop time,

the first hematocrit value is larger than the second hematocrit value,

the first voltage is smaller than the second voltage, and

the second application time is longer than the first application time.

2. The biological information measurement device according to claim 1, wherein a clock is connected to the control portion.

3. The biological information measurement device according to claim 1,

wherein a determination portion is connected to the control portion, and compares a current flowing between the second electrode and the third electrode through the second input terminal and the third input terminal with a threshold value.