Measuring chamber for an optical sensor for determining a concentration of a substance in the tissue fluid of a mammal
First Claim
1. A measurement chamber device for an optical sensor for measuring the concentration of a substance in the interstitial liquid of a mammal, wherein the measurement chamber device comprises:
- a measurement chamber, wherein the measurement chamber is filled with a measurement liquid and comprises a wall, the wall including at least one wall section enabling a better diffusion of the substance than of other components of the interstitial liquid, the measurement chamber, further including a first measurement chamber window section receiving a transmitter unit for emitting optical radiation into the measurement chamber and a second measurement chamber window section receiving a receiver unit for detecting optical radiation transmitted through the measurement chamber, the measurement chamber device further comprising a sterilization envelope which encloses the wall section of the measurement chamber but does not block the optical radiation at the measurement chamber window sections, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber windows, wherein each of the pair of openings is sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section, respectively, wherein the sterilization envelope is filled with measurement liquid to bathe the wall section in measurement liquid, and wherein the sterilization envelope is selectively removable before use of the measurement chamber.
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Accused Products
Abstract
A measuring chamber device for an optically operating sensor for determining a concentration of a substance that is contained in tissue fluid of a mammal. The measuring chamber device has a measuring chamber filled with a liquid measuring medium and a wall with better diffusion permeability for the substance than for other constituents of the tissue fluid. A transmitter device for emitting optical radiation into the measuring chamber, and a receiver device for receiving optical radiation that has passed through the measuring chamber are also provided.
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Citations
22 Claims
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1. A measurement chamber device for an optical sensor for measuring the concentration of a substance in the interstitial liquid of a mammal, wherein the measurement chamber device comprises:
a measurement chamber, wherein the measurement chamber is filled with a measurement liquid and comprises a wall, the wall including at least one wall section enabling a better diffusion of the substance than of other components of the interstitial liquid, the measurement chamber, further including a first measurement chamber window section receiving a transmitter unit for emitting optical radiation into the measurement chamber and a second measurement chamber window section receiving a receiver unit for detecting optical radiation transmitted through the measurement chamber, the measurement chamber device further comprising a sterilization envelope which encloses the wall section of the measurement chamber but does not block the optical radiation at the measurement chamber window sections, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber windows, wherein each of the pair of openings is sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section, respectively, wherein the sterilization envelope is filled with measurement liquid to bathe the wall section in measurement liquid, and wherein the sterilization envelope is selectively removable before use of the measurement chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A module for a sensor for measuring a concentration of a substance, the module comprising a measurement chamber device including a measurement chamber and filled with a measurement liquid, the chamber comprising a wall including at least one wall section enabling a better diffusion of the substance than of other components of the interstitial liquid, the measurement chamber device further comprising a first measurement chamber window section designed to be connected to a transmitter unit for emitting optical radiation into the measurement chamber and a second measurement chamber window section designed to be connected to a receiver unit for detecting optical radiation transmitted through the measurement chamber, wherein the wall and the measurement window sections enclose the measurement liquid, and the device further comprising a sterilization envelope enclosing the wall section of the measurement chamber, wherein the sterilization envelope is filled also with measurement liquid to bathe the wall section in measurement liquid, and wherein the measurement chamber is elongated having a length and a pair of opposing ends, the first measurement chamber window section being located at one end and the second measurement chamber window section being located at the opposing end, the measurement chamber being adapted for transmission of the optical radiation along the length without reflection, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber window sections, wherein each of the pair of openings is sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section respectively.
- 16. A sensor for measuring a concentration of a substance, the sensor comprising a transmitter unit for emitting optical radiation, a receiver unit for receiving the optical radiation, and a measurement chamber device, the measurement chamber device comprising a measurement chamber and filled with a measurement liquid, the measurement chamber comprising a wall including at least one wall section enabling a better diffusion of the substance than of other components of the interstitial liquid, the measurement chamber further comprising a first measurement chamber window section adapted to receive the transmitter unit, and a second measurement chamber window section receiving the receiver unit, wherein the wall and the measurement window sections enclose the measurement liquid, the measurement chamber device further comprising a sterilization envelope enclosing the wall section of the measurement chamber, the sterilization envelope being filled with measurement liquid to bathe the wall section in measurement liquid, and being selectively removable before use of the measurement chamber, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber window sections, wherein each of the pair of openings is sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section, respectively.
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20. A method for producing a measurement chamber device, the measurement chamber device comprising a measurement chamber having a wall with at least one wall section enabling better diffusion of a substance contained in interstitial liquid than of other substances contained in the interstitial liquid, the measurement chamber further having a first measurement chamber window section and a second measurement chamber window section, the measurement chamber device further including a sterilization envelope enclosing the wall section of the measurement chamber, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber windows, each of the pair of openings being sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section, respectively, the method comprising:
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a) enclosing the measurement chamber in the sterilization envelope; b) filling the measurement chamber and sterilization envelope with the measurement liquid under vacuum conditions and closing a port in the sterilization envelope; and c) sterilizing the filled unit with ionizing radiation.
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21. A method for producing a module for a sensor for measuring a concentration of a substance, the module comprising a measurement chamber device including a measurement chamber, the chamber comprising a wall including at least one wall section enabling a better diffusion of the substance in the interstitial liquid than of other components of the interstitial liquid, the measurement chamber device further comprising a first measurement chamber window section designed to be connected to a transmitter unit for emitting optical radiation into the measurement chamber and a second measurement chamber window section designed to be connected to a receiver unit for detecting optical radiation transmitted through the measurement chamber, the device further comprising a sterilization envelope enclosing the wall section of the measurement chamber, the measurement chamber being elongated having a length and a pair of opposing ends, the first measurement chamber window section being located at one end and the second measurement chamber window section being located at the opposing end, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber window sections, wherein each of the pair of openings is sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section, respectively, the method comprising:
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a) enclosing the measurement chamber in the sterilization envelope; b) filling the measurement chamber and sterilization envelope with the measurement liquid under vacuum conditions and closing a port in the sterilization envelope; c) sterilizing the measurement chamber and sterilization envelope with ionizing radiation; and d) connecting the transmitter unit to the measurement window section, and sterilizing the transmitter unit by surface sterilization.
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22. A method for producing a sensor for measuring a concentration of a substance, the sensor comprising a transmitter unit for emitting optical radiation, a receiver unit for receiving the optical radiation, and a measurement chamber device, the measurement chamber device comprising a measurement chamber and filled with a measurement liquid, the measurement chamber comprising a wall including at least one wall section enabling a better diffusion of the substance than of other components of the interstitial liquid, the measurement chamber further comprising a first measurement chamber window section adapted to receive the transmitter unit, and a second measurement chamber window section receiving the receiver unit, the measurement chamber device further comprising a sterilization envelope enclosing the wall section of the measurement chamber, the sterilization envelope being selectively removable before use of the measurement chamber, the sterilization envelope defining a pair of openings in opposing walls thereof corresponding to the measurement chamber window sections, wherein each of the pair of openings is sealingly coupled to the measurement chamber around the first measurement chamber window section and the second measurement chamber window section, respectively, the method comprising:
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a) enclosing the measurement chamber in the sterilization envelope; b) connecting a calibration chamber containing a calibration liquid to the sterilization envelope via a liquid connection, the liquid connection being selectively openable and closable; c) filling the measurement chamber and sterilization envelope with the measurement liquid under vacuum conditions and closing a port in the sterilization envelope; d) sterilizing the measurement chamber and sterilization envelope with ionizing radiation; e) connecting the receiver unit to the second measurement chamber window section and connecting the transmitter unit to the first measurement window section; and f) calibrating the sensor by performing a first measurement with the liquid connection closed, subsequently opening the liquid connection to mix the measurement liquid with the calibration liquid, and performing a second measurement with the measurement liquid being mixed with the calibration liquid.
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Specification