Noninvasive physiological analysis using excitation-sensor modules and related devices and methods
First Claim
1. A method of assessing blood pressure in an organism, the method comprising:
- directing light at one or more regions of the organism via at least two optical emitters, wherein at least one optical emitter generates light at a first wavelength, wherein at least one other optical emitter generates light at a second wavelength shorter than the first wavelength, and wherein the second wavelength is in the range of blue-UV;
detecting, via an optical detector, light at the first and second wavelengths scattered from the organism and generating, via the optical detector, a first electrical signal associated with the first wavelength and a second electrical signal associated with the second wavelength; and
processing, via at least one processor, the first and second electrical signals, wherein the processing comprises;
filtering each of the first and second electrical signals with respect to skin motion noise to generate a first extracted signal associated with the first wavelength and a second extracted signal associated with the second wavelength that is distinct from the first extracted signal, wherein the first extracted signal comprises information about blood flow through a blood vessel of the organism, and wherein the second extracted signal comprises information about size of the blood vessel; and
comparing the first extracted signal and the second extracted signal, responsive to generation of each by the filtering with respect to the skin motion noise, in context of a physiological model to assess the blood pressure of the organism, wherein the comparing comprises;
calculating the blood pressure of the organism based on an area of the blood vessel and based on a volumetric flow rate of blood therein, wherein the area is based on the size of the blood vessel and a change in the size thereof indicated by the second extracted signal, and wherein the volumetric flow rate is indicated by the first extracted signal.
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Abstract
Methods and apparatus for qualifying and quantifying excitation-dependent physiological information extracted from wearable sensors in the midst of interference from unwanted sources are provided. An organism is interrogated with at least one excitation energy, energy response signals from two or more distinct physiological regions are sensed, and these signals are processed to generate an extracted signal. The extracted signal is compared with a physiological model to qualify and/or quantify a physiological property. Additionally, important physiological information can be qualified and quantified by comparing the excitation wavelength-dependent response, measured via wearable sensors, with a physiological model.
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Citations
10 Claims
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1. A method of assessing blood pressure in an organism, the method comprising:
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directing light at one or more regions of the organism via at least two optical emitters, wherein at least one optical emitter generates light at a first wavelength, wherein at least one other optical emitter generates light at a second wavelength shorter than the first wavelength, and wherein the second wavelength is in the range of blue-UV; detecting, via an optical detector, light at the first and second wavelengths scattered from the organism and generating, via the optical detector, a first electrical signal associated with the first wavelength and a second electrical signal associated with the second wavelength; and processing, via at least one processor, the first and second electrical signals, wherein the processing comprises; filtering each of the first and second electrical signals with respect to skin motion noise to generate a first extracted signal associated with the first wavelength and a second extracted signal associated with the second wavelength that is distinct from the first extracted signal, wherein the first extracted signal comprises information about blood flow through a blood vessel of the organism, and wherein the second extracted signal comprises information about size of the blood vessel; and comparing the first extracted signal and the second extracted signal, responsive to generation of each by the filtering with respect to the skin motion noise, in context of a physiological model to assess the blood pressure of the organism, wherein the comparing comprises; calculating the blood pressure of the organism based on an area of the blood vessel and based on a volumetric flow rate of blood therein, wherein the area is based on the size of the blood vessel and a change in the size thereof indicated by the second extracted signal, and wherein the volumetric flow rate is indicated by the first extracted signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification